Journal Article10.1097/PAI.0B013E3181E181B1
Expression of 6 common antigenic markers in invasive ductal breast carcinoma: potential clinical implications.
Theodore Lialiaris,Alexandros Kouskoukis,Georgios Georgiou,Gregory Tripsianis,Aliki Fiska,Alexandra Giatromanolaki,Sofia Chrisafi,Efthimios Sivridis,Dimitra N. Vamvakopoulou,Despina O. Soutopoulou,Aspasia Kiritsaka,Evangelos Athanassiou,Georgios Lialios,Sotirios Sotiriou,Andreas Sidiropoulos,Nicholas C. Vamvakopoulos +15 more
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TL;DR: The findings support the diagnostic and potential prognostic value of these markers in the clinical assessment of breast cancer.
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Abstract: Expression of estrogen (ER) and progesterone receptors, c-erbB-2 oncogene, mutant p53 antioncogene (mp53), e-cadherin adhesion, and apoptotic caspase-8 antigens in tumor relative to matched normal tissue specimens from 102 unselected patients with primary ductal breast carcinoma of various tumor grades was assessed by immunohistochemistry and correlated with patient's biologic and clinical features, such as age, menstrual status, age of menarche, tumor grade and diameter, the presence or absence of metastases, and number of infiltrated lymph nodes. We observed association of e-cadherin adhesion, ER and progesterone antigen marker expression with low histologic grade tumors and limited number of lymph node metastases and of c-erbB-2, mp53, and casp-8 antigen marker expression with high histologic grade tumors and increased number of lymph node metastases. We also observed strong correlation (P<0.05) between 4 of the 6 biomarkers and 4 of the 7 patient/tumor parameters examined. Our findings support the hypothesis of independent expression of these 4 strong biomarkers and reveal that nearly 40% of all breast tumor cases studied express similar proportions of 2 major phenotypic combinations [ER/c-erbB-2/mp53/casp-8: +/+/-/+ (19.6%) & +/-/-/+ (17.8%)]. We conclude that, in agreement with earlier reports, our findings support the diagnostic and potential prognostic value of these markers in the clinical assessment of breast cancer.
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TL;DR: The illustrations are clear and the book is easy to read as the paper is variety, and perhaps this is not a book for pathologists to purchase-yet there should be a place for it in every hospital library.
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References
Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies.
TL;DR: Levels of endogenous sex hormones are strongly associated with breast cancer risk in postmenopausal women, and SHBG was associated with a decrease in Breast cancer risk.
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
Vladimir J.N. Bykov,Natalia Issaeva,Alexandre Shilov,Monica Hultcrantz,Elena N. Pugacheva,Peter M. Chumakov,Jan Bergman,Klas G. Wiman,Galina Selivanova +8 more
TL;DR: This work found one compound capable of inducing apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53, named PRIMA-1, which rescued both DNA contact and structural p53 mutants in vitro and in living cells.
Ackerman's Surgical Pathology
TL;DR: The illustrations are clear and the book is easy to read as the paper is variety, and perhaps this is not a book for pathologists to purchase-yet there should be a place for it in every hospital library.
735
Endogenous Estrogen, Androgen, and Progesterone Concentrations and Breast Cancer Risk Among Postmenopausal Women
TL;DR: Circulating levels of sex steroid hormones may be most strongly associated with risk of ER+/PR+ breast tumors, but there were no statistically significant associations between this risk and the level of progesterone or sex hormone binding globulin.
557
Cadherins and catenins in breast cancer
TL;DR: Animal models of ILC provide mechanistic insight, confirming that E-cadherin serves as both a tumor suppressor and an invasion suppressor in ILC and suggests its oncogenic function in breast relates to its role in mammary progenitor cell expansion.
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