Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles
TL;DR: Specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies are highlighted.
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Abstract: Nanoparticles (NPs) have remarkable properties for delivering therapeutic drugs to the body’s targeted cells. NPs have shown to be significantly more efficient as drug delivery carriers than micron-sized particles, which are quickly eliminated by the immune system. Biopolymer-based polymeric nanoparticles (PNPs) are colloidal systems composed of either natural or synthetic polymers and can be synthesized by the direct polymerization of monomers (e.g., emulsion polymerization, surfactant-free emulsion polymerization, mini-emulsion polymerization, micro-emulsion polymerization, and microbial polymerization) or by the dispersion of preformed polymers (e.g., nanoprecipitation, emulsification solvent evaporation, emulsification solvent diffusion, and salting-out). The desired characteristics of NPs and their target applications are determining factors in the choice of method used for their production. This review article aims to shed light on the different methods employed for the production of PNPs and to discuss the effect of experimental parameters on the physicochemical properties of PNPs. Thus, this review highlights specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies.
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Citations
Polymeric Nanoparticles for Drug Delivery.
Maximilian A Beach,Umeka Nayanathara,Yanting Gao,Changhe Zhang,Yijun Xiong,Yufu Wang,Georgina Such +6 more
TL;DR: This review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.
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TL;DR: A review of the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems is presented in this paper .
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A review on nanomaterial-based additive manufacturing: dynamics in properties, prospects, and challenges
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TL;DR: This review synthesizes the latest research on nanomaterial-based additive manufacturing, highlighting its enhanced properties, diverse applications, and potential to revolutionize the manufacturing industry, while addressing current challenges and future research directions.
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Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies
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Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications
Harish Bhardwaj,Rajendra Jangde +1 more
- 01 Jun 2023
TL;DR: This review summarizes the preparation and biomedical applications of polymeric nanoparticles (PNPs) as drug carriers, highlighting their biodegradability, biocompatibility, and high drug-loading capacity, with potential for targeted delivery in various diseases.
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