Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles
TL;DR: Specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies are highlighted.
read more
Abstract: Nanoparticles (NPs) have remarkable properties for delivering therapeutic drugs to the body’s targeted cells. NPs have shown to be significantly more efficient as drug delivery carriers than micron-sized particles, which are quickly eliminated by the immune system. Biopolymer-based polymeric nanoparticles (PNPs) are colloidal systems composed of either natural or synthetic polymers and can be synthesized by the direct polymerization of monomers (e.g., emulsion polymerization, surfactant-free emulsion polymerization, mini-emulsion polymerization, micro-emulsion polymerization, and microbial polymerization) or by the dispersion of preformed polymers (e.g., nanoprecipitation, emulsification solvent evaporation, emulsification solvent diffusion, and salting-out). The desired characteristics of NPs and their target applications are determining factors in the choice of method used for their production. This review article aims to shed light on the different methods employed for the production of PNPs and to discuss the effect of experimental parameters on the physicochemical properties of PNPs. Thus, this review highlights specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Polymeric Nanoparticles for Drug Delivery.
Maximilian A Beach,Umeka Nayanathara,Yanting Gao,Changhe Zhang,Yijun Xiong,Yufu Wang,Georgina Such +6 more
TL;DR: This review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.
152
Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications
TL;DR: A review of the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems is presented in this paper .
46
A review on nanomaterial-based additive manufacturing: dynamics in properties, prospects, and challenges
Mustafijur Rahman,Kazi Sirajul Islam,Tanvir Mahady Dip,Mohammed Farhad Mahmud Chowdhury,Smita Rani Debnath,Shah Md. Maruf Hasan,Md. Sadman Sakib,Tanushree Saha,Rajiv Padhye,Shadi Houshyar +9 more
TL;DR: This review synthesizes the latest research on nanomaterial-based additive manufacturing, highlighting its enhanced properties, diverse applications, and potential to revolutionize the manufacturing industry, while addressing current challenges and future research directions.
43
Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies
TL;DR: The aim of this review is to focus on the use of nanoscale polymeric particles in the treatment of colorectal cancer, breast cancer, ovarian cancer and glioblastoma multiforme, and to consider their potential use in cancer gene therapy.
Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications
Harish Bhardwaj,Rajendra Jangde +1 more
- 01 Jun 2023
TL;DR: This review summarizes the preparation and biomedical applications of polymeric nanoparticles (PNPs) as drug carriers, highlighting their biodegradability, biocompatibility, and high drug-loading capacity, with potential for targeted delivery in various diseases.
38
References
Polymer-Based Nanomaterials for Drug-Delivery Carriers
Hemant K.S. Yadav,Aiah A. Almokdad,Sumia I.M. shaluf,Manar Samir Debe +3 more
- 01 Jan 2019
TL;DR: This chapter will discuss the nanomaterials that are being formulated using polymers in drug-delivery systems, the different types used, and their preparation, including the various areas where they are applied, how to characterize them, and any challenges faced while they are being handled.
119
Nanoprecipitation is more efficient than emulsion solvent evaporation method to encapsulate cucurbitacin I in PLGA nanoparticles.
TL;DR: It is likely that cucurbitacin I escapes with the organic solvent after the emulsification step to the aqueous phase leading to ineffective entrapment in the polymeric matrix, therefore, nanoprecipitation method increases cucURbitacIn I entrapments in PLGA NPs and possibly other water-insoluble polar drugs.
Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method
TL;DR: It was concluded that nanocapsules of controlled size could be obtained upon optimizing certain process parameters based on the influence of the sonication process on the characteristics of poly(lactide-co-glycolide) nanocapules prepared by the water- in-oil-in-water solvent evaporation method.
114
Improvement of Nanoprecipitation Technique for Preparation of Gelatin Nanoparticles and Potential Macromolecular Drug Loading
Saeed Ahmad Khan,Marc Schneider +1 more
TL;DR: The entrapment efficiency of fluorescein-isothiocyanate (FITC)-dextran as model drug was determined to 50% with no substantial effect on particle size and 80% of the drug is only released after enzymatic digestion.
113
Emulsifier-free core–shell polyacrylate latex nanoparticles containing fluorine and silicon in shell
TL;DR: In this article, the emulsifier-free core-shell polyacrylate latex nanoparticles containing fluorine and silicon in shell were successfully synthesized by emulsifiers-free seeded emulsion polymerization with water as the reaction medium.
112
Related Papers (5)
[...]