Journal Article10.1016/J.BIOTECHADV.2011.03.007
Experimental methods and modeling techniques for description of cell population heterogeneity.
R Lencastre Fernandes,Marta Nierychlo,Luisa Lundin,AE Pedersen,P.E. (Pilar) Puentes Tellez,Abhishek Dutta,Magnus Carlquist,Andrijana Bolic,Daniel Schäpper,Anna Chiara Brunetti,S Helmark,A-L Heins,Anker Degn Jensen,Ingmar Nopens,Karsten Rottwitt,Nicolas Szita,J. D. van Elsas,Per Halkjær Nielsen,Jan Martinussen,Søren J. Sørensen,Adam Lantz,Krist V. Gernaey +21 more
135
TL;DR: The potential of currently available methods for monitoring cell population heterogeneity as well as model frameworks suitable for describing dynamic heterogeneous cell populations are summarized.
read more
About: This article is published in Biotechnology Advances. The article was published on 01 Nov 2011.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
Levente L. Simon,Hajnalka Pataki,György Marosi,Fabian Meemken,Konrad Hungerbühler,Alfons Baiker,Srinivas Tummala,Brian Glennon,Martin Kuentz,Gerry Steele,Herman J. M. Kramer,James W. Rydzak,Zeng-Ping Chen,Julian Morris,Francois Kjell,Ravendra Singh,Rafiqul Gani,Krist V. Gernaey,Marjatta Louhi-Kultanen,John Oreilly,Niklas Sandler,Osmo Antikainen,Jouko Yliruusi,Patrick Frohberg,Joachim Ulrich,Richard D. Braatz,Tom Leyssens,Moritz von Stosch,Rui Oliveira,Reginald B. H. Tan,Huiquan Wu,Mansoor A. Khan,Des O'grady,Anjan Pandey,Remko Westra,Emmanuel Delle-Case,Detlef Pape,Daniele Angelosante,Yannick Maret,Olivier Steiger,Miklos Lenner,Kaoutar Abbou-Oucherif,Zoltan K. Nagy,James D. Litster,Vamsi Krishna Kamaraju,Min-Sen Chiu +45 more
TL;DR: In this paper, a multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture.
400
Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis.
TL;DR: In vivo population quality control (PopQC) is developed to continuously select for high-performing, nongenetic variants of biosynthetic pathways and it is confirmed that PopQC improves ensemble biosynthesis by selecting for nonganetic high performers.
250
The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids.
TL;DR: A biosensor based on the transcriptional regulator Lrp that detects intracellular l-methionine and branched-chain amino acids in Corynebacterium glutamicum was developed and successfully used in a high-throughput (HT) FACS screen for the isolation of amino acid-producing mutants after random mutagenesis of a non-producing wild type strain.
218
A perspective on PSE in pharmaceutical process development and innovation
TL;DR: The central role of Process Systems Engineering methods and tools in pharmaceutical process development and innovation is discussed, and questions such as: Which PSE methods can be applied readily?
147
Bio-production of lactobionic acid: Current status, applications and future prospects
TL;DR: The present review explores recent advances and studies related to lactobionic acid bio-production, whether through microbial or enzymatic approaches, highlighting the key bioprocessing conditions for enhanced bio- production.
145
References
Semiconductor Clusters, Nanocrystals, and Quantum Dots
TL;DR: In this article, the authors focus on the properties of quantum dots and their ability to join the dots into complex assemblies creates many opportunities for scientific discovery, such as the ability of joining the dots to complex assemblies.
11.6K
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Green fluorescent protein as a marker for gene expression
TL;DR: A complementary DNA for the Aequorea victoria green fluorescent protein produces a fluorescent product when expressed in prokaryotic or eukaryotic cells, which can be used to monitor gene expression and protein localization in living organisms.
7.4K
A novel genetic system to detect protein-protein interactions.
Stanley Fields,Ok-kyu Song +1 more
TL;DR: A novel genetic system to study protein-protein interactions between two proteins by taking advantage of the properties of the GAL4 protein of the yeast Saccharomyces cerevisiae, which may be applicable as a general method to identify proteins that interact with a known protein by the use of a simple galactose selection.
7K
The green fluorescent protein
TL;DR: In just three years, the green fluorescent protein from the jellyfish Aequorea victoria has vaulted from obscurity to become one of the most widely studied and exploited proteins in biochemistry and cell biology.
Related Papers (5)
Sven-Olof Enfors,Mehmedalija Jahic,A. Rozkov,Bo Xu,Michael Hecker,Britta Jürgen,Elke Krüger,Thomas Schweder,G. Hamer,D. O'Beirne,Naruemol Noisommit-Rizzi,Matthias Reuss,L. Boone,Christopher J. Hewitt,Caroline M. McFarlane,Alvin W. Nienow,Tamas Kovacs,Christian Trägårdh,Laszlo Fuchs,Johan Revstedt,P. C. Friberg,Bjørn H. Hjertager,G. Blomsten,Harald Skogman,S. Hjort,Frans W. J. M. M. Hoeks,H. Y. Lin,Peter Neubauer,R. G. J. M. van der Lans,Karel Ch. A. M. Luyben,Peter Vrábel,A. Manelius +31 more