Journal Article10.1111/SRT.12125
Experimental and numerical analysis of soft tissue stiffness measurement using manual indentation device--significance of indentation geometry and soft tissue thickness.
44
TL;DR: Indentation techniques have been applied to measure stiffness of human soft tissues and the geometry of the indentation instrument control the measured response.
read more
Abstract: Background
Indentation techniques haves been applied to measure stiffness of human soft tissues. Tissue properties and geometry of the indentation instrument control the measured response.
Methods
Mechanical roles of different soft tissues were characterized to understand the performance of the indentation instrument. An optimal instrument design was investigated. Experimental indentations in forearm of human subjects (N = 11) were conducted. Based on peripheral quantitative computed tomography imaging, a finite element (FE) model for indentation was created. The model response was matched with the experimental data.
Results
Optimized values for the elastic modulus of skin and adipose tissue were 130.2 and 2.5 kPa, respectively. The simulated indentation response was 3.9 ± 1.2 (mean ± SD) and 4.9 ± 2.0 times more sensitive to changes in the elastic modulus of the skin than to changes in the elastic modulus of adipose tissue and muscle, respectively. Skin thickness affected sensitivity of the instrument to detect changes in stiffness of the underlying tissues.
Conclusion
Finite element modeling provides a feasible method to quantitatively evaluate the geometrical aspects and the sensitivity of an indentation measurement device. Systematically, the skin predominantly controlled the indentation response regardless of the indenter geometry or variations in the volume of different soft tissues.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Perioperative and posttraumatic anti-edematous decongestive device-based negative pressure treatment for anti-edematous swelling treatment of the lower extremity - a prospective quality study
Klaus Dresing,Ann-Christin Fischer,Wolfgang Lehmann,Dominik Saul,Christopher Spering +4 more
- 01 Jan 2021
TL;DR: In this article, a negative pressure was applied locally by using LymphaTouch® device (LT) with a silicone-coated applicator to reduce posttraumatic and perioperative swelling of the lower extremity effectively and sustainably.
24
Accuracy and reliability of a hand-held in vivo skin indentation device to assess skin elasticity.
TL;DR: The aim of this study was to evaluate the performance of a hand‐held indentation device for fast and reliable determination of skin stiffness.
21
A dose-ranging, parallel group, split-face, single-blind phase II study of light emitting diode-red light (LED-RL) for skin scarring prevention: study protocol for a randomized controlled trial.
Julie K. Nguyen,Jeremy Weedon,Jeannette Jakus,Edward Heilman,Roslyn Rivkah Isseroff,Roslyn Rivkah Isseroff,Daniel M. Siegel,Jared Jagdeo +7 more
TL;DR: The results from this study may change the current treatment paradigm for fibrotic skin diseases and help to pioneer LED-RL as a safe, non-invasive, cost-effective, portable, at-home therapy for scars.
Elastic instability during branchial ectoderm development causes folding of the Chlamydosaurus erectile frill
Sophie A. Montandon,Anamarija Fofonjka,Anamarija Fofonjka,Michel C. Milinkovitch,Michel C. Milinkovitch +4 more
TL;DR: It is suggested that the ancestor of Episquamata reptiles developed a neck fold from the hyoid branchial arch by preventing it to fully fuse with posterior arches, and it is shown that the Chlamydosaurus embryonic neck fold dramatically enlarges and its anterior surface wrinkles, establishing three convex ridges on each lobe of the frill.
11
References
Collagen : structure and mechanics
Peter Fratzl
- 01 Jan 2008
TL;DR: This chapter discusses Collagen and the Mechanical Properties of Bone and Calcified Cartilage, as well as biomimetic Collagen Tissues: Collagenous Tissue Engineering and Other Applications.
897
Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples
TL;DR: Specialized techniques to measure tissue elasticity of breast normal tissues and tumour specimens and applied them to 169 fresh ex vivo breast tissue samples as well as a range of benign and malignant breast tumour types show that, under small deformation conditions, the elastic modulus of normal breast fat and fibroglandular tissues are similar while fibroadenomas were approximately twice the stiffness.
734
In vivo model of the mechanical properties of the human skin under suction.
S. Diridollou,Frédéric Patat,Fabrice Gens,Loïc Vaillant,D. Black,J. M. Lagarde,Y. Gall,M. Berson +7 more
TL;DR: A new method for the in vivo characterization of the mechanical properties of skin has been developed that comprises a suction chamber and an ultrasound device to measure both the vertical displacement of the skin's surface, and the skin’s thickness.
390
A numerical-experimental method to characterize the non-linear mechanical behaviour of human skin
FM Falke Hendriks,Dirk Brokken,van Jtwm Eemeren,Cwj Cees Oomens,Fpt Frank Baaijens,Jbam Joost Horsten +5 more
TL;DR: A numerical‐experimental method was developed to characterize the non‐linear mechanical behaviour of human dermis, and the mechanical properties of the different layers are studied.
373
The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments
TL;DR: The in vivo mechanical behavior of the upper skin layer (here defined as epidermis and papillar dermis) was characterized using a combined experimental and modeling approach, leading to an unexpected, extreme stiffness ratio of the material parameters let to convergence problems of the finite element software for most of the individuals.
347