Exosomes: extracellular organelles important in intercellular communication.

TL;DR: In this paper , the authors used ex vivo, in vitro, and in vivo models, to investigate the characteristics and functions of migrasomes in RPE activation and PVR development.

TL;DR: The role of exosomes in the three phases of tumor immunoediting is introduced in detail, and relevant literature on exosome in the tumor immune microenvironment is summarized by using a novel framework for extracting relevant documents as discussed by the authors .

TL;DR: The mesenchymal stem cells used in this study were genetically engineered to obtain exosomes with high CXCR4 expression as carriers for targeted gene-drug delivery, and the Survivin gene was loaded via electrotransformation to construct a brand-new gene- drug delivery system (CXCR 4high Exo/si-Survivin).

TL;DR: Recent progress on stem cell-based therapeutic approaches for tendon repair is reviewed, which highlights its translational potential and challenges, and current understanding of the underlying mechanisms of the approach.

TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.

TL;DR: It is demonstrated by immunoelectron microscopy that the limiting membrane of MIICs can fuse directly with the plasma membrane, resulting in release from the cells of internal MHC class II-containing vesicles, suggesting a role for exosomes in antigen presentation in vivo.

TL;DR: Crosstalk between multiple Rab GTPases through shared effectors, or through effectors that recruit selective Rab activators, ensures the spatiotemporal regulation of vesicle traffic.

TL;DR: It is found that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of theendosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide.