Exocytosis: a molecular and physiological perspective.
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TL;DR: Some of the recent advances in Ca microdomains are summarized and P/Q-type high-voltage-activated Ca channels, ascurrent directions of research in this active field are indicated.
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About: This article is published in Neuron. The article was published on 01 Dec 1996. and is currently open access. The article focuses on the topics: Perspective (graphical).
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Citations
Basal somatodendritic dopamine release requires snare proteins.
TL;DR: This work established for the first time a rat primary neuron culture model and used it to study the mechanism under conditions of non‐stimulated spontaneous firing, providing direct and unambiguous evidence for the involvement of an exocytotic mechanism in basal spontaneous somatodendritic dopamine release.
Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells
Sebastian Barg,Charlotta S. Olofsson,Jenny Schriever-Abeln,Anna Wendt,Samuel Gebre-Medhin,Erik Renström,Patrik Rorsman +6 more
TL;DR: Study of exocytotic membrane fusion and cargo release in neuroendocrine cells concludes that RRP refilling involves chemical modification of vesicles already in place, the release of large neuropeptides via the fusion pore is negligible and only proceeds after complete fusion, and sluggish peptidergic transmission reflects the time course ofvesicle emptying.
Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic β-cells
Hai-Qiang Dou,Yunfei Xu,Jin-Peng Sun,Shujiang Shang,Shu Guo,Lianghong Zheng,Chao-chao Chen,Iain C. Bruce,Xiao Yu,Zhuan Zhou +9 more
TL;DR: Thiopental-induced insulin secretion is mediated by activation of the intracellular IP(3)-sensitive Ca(2+) store, particularly in relation to drug stimuli.
Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.
TL;DR: During physiologically relevant firing patterns in aging neurons, post Synaptic Ca2+ elevation is closely associated with altered neuronal plasticity and selectively increasing postsynaptic L-VSCC activity, as occurs in aging, negatively regulated a form of short-term plasticity that enhances synaptic throughput.
Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor.
Misa Shimuta,Masahiro Yoshikawa,Masahiro Fukaya,Masahiko Watanabe,Hiroshi Takeshima,Toshiya Manabe,Toshiya Manabe +6 more
TL;DR: It is concluded that RyR3 postsynaptically regulates the properties of AMPA receptors and LTP, and the initial potentiation following tetanic stimulation of afferent fibers was similar, but long-term potentiation was smaller in mutant mice.
References
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.
Martin Geppert,Yukiko Goda,Robert E. Hammer,Cai Li,Thomas W. Rosahl,Charles F. Stevens,Thomas C. Südhof +6 more
TL;DR: It is proposed that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2-regulation of synchronous neurotransmitter release in hippocampal neurons and not essential for asynchronous or Ca(2+)-independent release.
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Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
TL;DR: Current understanding of the mechanism by which synapsin I modulates communication between nerve cells is described and the properties and putative functions of other phosphoproteins associated with synaptic vesicles are reviewed.
1.3K
Definition of the Readily Releasable Pool of Vesicles at Hippocampal Synapses
TL;DR: It is found that hypertonic solutions do not act through changes in intracellular calcium, which means that the synaptic release probability depends on the size of the readily releasable pool.
1.1K
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission
TL;DR: A role for alpha 1A subunits in synaptic transmission is suggested and the idea that neurotransmitter release may depend on multiple types of calcium channels under physiological conditions is supported.
999
Calcium dependence of the rate of exocytosis in a synaptic terminal
TL;DR: A given synaptic vesicle can exocytose with high probability within a few hundred microseconds, if [Ca2+]i rises above lOOµM, and these properties provide for the extremely rapid signalling required for neuronal communication.
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