Journal Article10.1152/JAPPLPHYSIOL.00012.2003
Exercise training improves conduit vessel function in patients with coronary artery disease
Jennifer H. Walsh,William Bilsborough,Andrew Maiorana,Matthew J. Best,Gerard O'Driscoll,Roger R. Taylor,Daniel J. Green +6 more
TL;DR: Exercise training improves endothelium-dependent conduit vessel dilation in subjects with CAD, and the effect appears to be generalized rather than limited to vessels of exercising muscle beds.
read more
Abstract: It is well established that endothelial dysfunction is present in coronary artery disease (CAD), although few studies have determined the effect of training on peripheral conduit vessel function in...
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Effect of exercise training on endothelium‐derived nitric oxide function in humans
TL;DR: Given the strong prognostic links between vascular structure, function and cardiovascular events, the implications of these findings are obvious, yet many unanswered questions remain, including the mechanisms responsible for NO bioactivity, the nature of the cellular effect and relevance of other autacoids, but also such practical questions as the optimal intensity, modality and volume of exercise training required in different populations.
1K
Vascular adaptation to exercise in humans: role of hemodynamic stimuli
TL;DR: This review focuses on "hemodynamic" forces associated with the movement of blood through arteries in humans and the functional and structural adaptations that result from repeated episodic exposure to such stimuli, and addresses the impact of distinct hemodynamic signals that occur in response to exercise.
Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure.
Rainer Hambrecht,Eduard Fiehn,Claudia Weigl,Stephan Gielen,Caroline Hamann,Ralf Kaiser,Jiangtao Yu,Volker Adams,Josef Niebauer,Gerhard Schuler +9 more
TL;DR: Regular physical exercise improves both basal endothelial nitric oxide (NO) formation and agonist-mediated endothelium-dependent vasodilation of the skeletal muscle vasculature in patients with CHF.
503
Impact of inactivity and exercise on the vasculature in humans
Dick H. J. Thijssen,Dick H. J. Thijssen,Andrew Maiorana,Andrew Maiorana,Gerry O'Driscoll,Gerry O'Driscoll,Nigel T. Cable,Maria T. E. Hopman,Daniel J. Green,Daniel J. Green +9 more
TL;DR: Evidence that inactivity and exercise have direct effects on both vasculature function and structure in humans and that both functional and structural remodelling adaptations occur depends upon training duration and intensity and the vessel beds involved is examined.
The Effect of Physical Exercise on Endothelial Function
Samanta Di Francescomarino,Adolfo Sciartilli,Valentina Di Valerio,Angela Di Baldassarre,Sabina Gallina +4 more
TL;DR: While strenuous exercise increases oxidative metabolism and produces a pro-oxidant environment, only regular moderate physical activity promotes an antioxidant state and preserves endothelial function.
318
References
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
21.2K
Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress
Hua Cai,David G. Harrison +1 more
TL;DR: Accumulating evidence suggests that oxidant stress alters many functions of the endothelium, including modulation of vasomotor tone, and as the role of these various enzyme sources of ROS become clear, it will perhaps be possible to use more specific therapies to prevent their production and ultimately correct endothelial dysfunction.
4K
Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors
TL;DR: Findings suggest that HMG CoA reductase inhibitors may have beneficial effects in atherosclerosis beyond that attributed to the lowering of serum cholesterol by increasing ecNOS activity.
1.9K