Evolution of the Cancer Stem Cell Model

TL;DR: In this article, a meta-analysis was conducted to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion and found that fibroblast growth factor 2 (FGF2) was the best candidate in T47D and BT549 cells, of which conditioned medium was previously successful in inducing CSCs.

TL;DR: The current understanding of how environmental exposures impact stem cell function relevant to carcinogenesis and cancer prevention is reviewed, with a focus on environmental and occupational exposures to chemical, physical, and biological hazards.

TL;DR: CD105/CD133 cannot be validated as cancer stem cell markers of pRCC cell lines, and the correlation of CD105 and/or CD133 expression with the enhancement of stem-like properties is observed.

TL;DR: The findings indicate the pivotal role of ALKBH5 in CSCs derived from NSCLC and highlight the regulatory function of the p53/AL KBH5 axis in modulating CSC progression, which could be a promising therapeutic target for NSCLCs.

TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.

TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.

TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.