Evolution of enzyme cascades from embryonic development to blood coagulation

TL;DR: In this paper, the authors show that the rate of the N ∗ → N transition is strongly correlated with the analogous E ∗→ E transition that governs the interaction of synthetic and physiologic substrates with the active site.

TL;DR: In this article , the authors show that the rate of the N∗→N transition is strongly correlated with the analogous E∗-E transition that governs the interaction of synthetic and physiologic substrates with the active site.

TL;DR: This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction in the Central American region.

TL;DR: In this paper , a clip domain serine protease and its alternative transcript (MncSP-isoform) were identified from Macrobrachium nipponense, and the full-length cDNA sequences of MncSP and its isoform were 2447 and 2351 bp.

TL;DR: A novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor is revealed.

TL;DR: It is suggested that the classification by families could be used as an extension of the current classification by catalytic type, and some of these contain members with quite diverse peptidase activities.

TL;DR: Cl cloning and characterization of a new human thrombin receptor, designated protease-activated receptor 3 (PAR3) is reported, which can mediate throm-bin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues, making it a candidate for the sought-after second platelet throm bin receptor.