Journal Article10.1016/S0968-0004(01)02007-2
Evolution of enzyme cascades from embryonic development to blood coagulation
Maxwell M. Krem,Enrico Di Cera +1 more
TL;DR: It is proposed that a single ancestral developmental/immunity cascade gave rise to the protostome and deuterostome developmental, clotting and complement cascades and were built by adding enzymes from the bottom of the cascade up and from similar macromolecular building blocks.
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About: This article is published in Trends in Biochemical Sciences. The article was published on 01 Feb 2002.
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Citations
Determinants of specificity in coagulation proteases
TL;DR: The mechanisms of substrate specificity employed by serine proteases are reviewed and the interplay between active site and exosite specificity and how substrate recognition is regulated allosterically by Na+ binding are dissected.
77
The role of coagulation/fibrinolysis during Streptococcus pyogenes infection.
TL;DR: This review summarizes the knowledge gained during the last two decades on the role of coagulation/fibrinolysis in host defense against S. pyogenes as well as the strategies developed by this pathogen to evade and exploit these host mechanisms for its own benefit.
Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor.
Young Moo Choo,Kwang Sik Lee,Hyung Joo Yoon,Yuling Qiu,Hu Wan,Mi Ri Sohn,Hung Dae Sohn,Byung Rae Jin +7 more
TL;DR: A novel mechanism by which bumblebee venom affects the hemostatic system through the antifibrinolytic activity of Bi-KTI and through Bi-VSP-mediated fibrin(ogen)olytic activities is demonstrated, raising interest in Bi- KTI and Bi- VSP as potential clinical agents.
Extracellular proteolytic cascade in tomato activates immune protease Rcr3.
Judith K Paulus,Jiorgos Kourelis,Selva Ramasubramanian,Felix Homma,Alice Godson,Anja C. Hörger,Tram Ngoc Hong,Tram Ngoc Hong,Daniel Krahn,Laura Ossorio Carballo,Shuaishuai Wang,Joe Win,Matthew Smoker,Sophien Kamoun,Suomeng Dong,Renier A. L. van der Hoorn,Renier A. L. van der Hoorn +16 more
TL;DR: It is shown that immune protease Rcr3, a secreted PLCP of tomato, is activated by secreted subtilisins, which are common serine proteases in plants, revealing a proteolytic cascade regulating extracellular immunity in solanaceous plants.
75
Molecular mechanisms of the shrimp clotting system.
TL;DR: The shrimp clotting system is reviewed and its involvement in innate immunity and the activation of antimicrobial peptides, similar to that of the horseshoe crab are reviewed.
73
References
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
3.8K
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
TL;DR: A novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor is revealed.
3.2K
Evolutionary families of peptidases
Neil D. Rawlings,Alan J. Barrett +1 more
TL;DR: It is suggested that the classification by families could be used as an extension of the current classification by catalytic type, and some of these contain members with quite diverse peptidase activities.
Protease-activated receptor 3 is a second thrombin receptor in humans.
Hiroaki Ishihara,Andrew J. Connolly,Dewan Zeng,Mark L. Kahn,Yaowu Zheng,Courtney Timmons,Tracy Tram,Shaun R. Coughlin +7 more
TL;DR: Cl cloning and characterization of a new human thrombin receptor, designated protease-activated receptor 3 (PAR3) is reported, which can mediate throm-bin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues, making it a candidate for the sought-after second platelet throm bin receptor.
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