Journal Article10.1016/0166-6851(85)90061-1
Evidence for the occurrence of respiratory electron transport in adult Brugia pahangi and Dipetalonema viteae.
Aruna H.W. Mendis,Simon Townson +1 more
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TL;DR: Respiratory studies on subcellular fractions substantiated the responses elicited by the intact parasites, suggesting the presence of antimycin A-sensitive and -insensitive RET pathways capable of utilising alpha-glycerophosphate, succinate, and malate as substrates.
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About: This article is published in Molecular and Biochemical Parasitology. The article was published on 01 Mar 1985. The article focuses on the topics: Brugia pahangi & Antimycin A.
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Citations
Caenorhabditis elegans: how good a model for veterinary parasites?
TL;DR: The organism about which most is known on a molecular level is a nematode, the free-living organism Caenorhabditis elegans, which has served as a reasonable model for the discovery of anthelmintic drugs and for research on the mechanism of action ofAnthelmintics.
139
Resistance of filarial nematode parasites to oxidative stress.
TL;DR: Data from cDNA cloning exercises indicate that all filarial species examined thus far express at least two peroxiredoxin variants which have been localised to diverse tissues, and these represent goals for future research.
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Branched Mitochondrial Electron Transport in the Animalia: Presence of Alternative Oxidase in Several Animal Phyla
TL;DR: It is hypothesized that alternative oxidase is likely widespread in the Animalia and some of the potential role(s) for such a branched respiratory chain are discussed.
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Cytostatic and cytotoxic effects of activated macrophages and nitric oxide donors on Brugia malayi.
TL;DR: Examination of ultrastructural changes on exposure of parasites to activated macrophages or donors of nitric oxide indicated that hypodermal mitochondria were highly vacuolated, with less prominent cristae, and it was suggested that peroxynitrite or its by-products were more potently damaging to filariae thanNitric oxide per se.
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Glutathione S-transferase in adult Dirofilaria immitis and Brugia pahangi.
Julian J. Jaffe,Roger A. Lambert +1 more
TL;DR: The ability of filarial glutathione S-transferases to detoxify electrophilic xenobiotics, at least those from D. immitis, suggests a potential role for these enzymes in the leukotriene synthetic pathway, if filariae can form such eicosanoids from arachidonate.
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References
Possible molecular mechanisms of the protonmotive function of cytochrome systems.
TL;DR: The newly introduced concepts of the protonmotive ubiquinone cycle, or Q cycle, and of the cyclic loop 2–3 system, which represent developments of the redox loop concept, are shown to provide a promising basis for the evolution of a satisfactory theory.
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Studies on the Metabolism of the Filarial Worm, Litomosoides carinii.
TL;DR: It is concluded that, in contrast to many other parasitic invertebrates, oxidative metabolism is essential for the survival of the filarial worm, L. carinii, and that the chemotherapeutic activity of the cyanine dyes in filariasis of the cotton rat is due to the inhibitory effect of this group of compounds on the respiratory metabolism of the parasite.
Comparative biochemical studies of Litomosoides carinii, Dipetalonema viteae, and Brugia pahangi adults.
Emma Jen Wang,Howard J. Saz +1 more
TL;DR: Findings suggest that the aerobic requirement of L. carinii may reside completely in one system, the oxidative decarboxyla- tion of pyruvate to acetate and CO2, which is considerably more readily reversible than the corresponding levo-isomer.
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Mechanisms of respiration and phosphorylation in Ascaris muscle mitochondria.
Peter Köhler,Roland Bachmann +1 more
TL;DR: Anaerobic and aerobic respiration was found to be associated with relatively low energy conservation efficiencies and no evidence could be obtained for a significant activity of energy conservation sites II and III and electron transfer through the alternative oxidase pathway was shown not to be coupled to phosphorylation.
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