Evidence for genetic variation as a factor in maintaining health
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TL;DR: This research has identified many sequence variations in the regulatory DNA of the genes coding for important members of the interleukin 1 family, and these variations are associated with differential effects on the inflammatory response, which alter the risk of some diseases in which inflammation plays a role and also affect physiologic responses, such as theinflammatory response to exercise.
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About: This article is published in The American Journal of Clinical Nutrition. The article was published on 01 Feb 2006. and is currently open access. The article focuses on the topics: Disease.
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References
•Journal Article
A rare allele combination of the interleukin-1 gene complex is associated with high interleukin-1 beta plasma levels in healthy individuals.
TL;DR: Data suggest that this allele combination has a regulatory effect on basal IL-1 beta production.
Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting
Adnan Kastrati,Werner Koch,Peter B. Berger,Julinda Mehilli,Katherine Stephenson,Franz-Josef Neumann,Nicolas von Beckerath,Corinna Böttiger,Gordon W. Duff,Albert Schömig +9 more
TL;DR: Allele 2 of the IL-1ra gene was associated with a lower incidence of restenosis after coronary stenting, particularly in younger patients, and this finding supports a role of inflammation in the development of restanosis after stent placement.