Journal Article10.1016/0014-2999(80)90259-9
Evidence for a presynaptic inhibitory action of 5-hydroxytryptamine on sympathetic neurotransmission to the myocardium
33
TL;DR: The results suggest that 5-HT inhibits sympathetic neurotransmission of the myocardium via an action on 'trypaminergic' receptors which may be located on sympathetic nerve terminal and that these receptors can be selectively blocked by cyproheptadine but not by methysergide.
read more
About: This article is published in European Journal of Pharmacology. The article was published on 16 May 1980. The article focuses on the topics: Cardiac nerve & Methysergide.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Serotonin and Blood Pressure Regulation
TL;DR: This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure, with a focus on the autonomic nervous system, and compares the change in blood pressure produced in different species by short- and long-term administration of5-HT or selective serotonin receptor agonists.
Neuronal 5-HT receptors in the periphery
TL;DR: Comparison of relative potencies of agonists suggests similarities with the 5-HT1 recognition site of the central nervous system; no selective antagonist has yet emerged to permit their positive identification.
328
Central cardiovascular control
D. Ganten,Donald W. Pfaff +1 more
- 01 Jan 1983
TL;DR: Central cardiovascular control, Central cardiovascular control , کتابخانه دیجیتال جندی شاپور اهواز
82
An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1C subtypes.
TL;DR: It is concluded that the receptor to 5-HT conforms to general criteria defining5-HT1-like receptors but at the present time the receptor site cannot be fitted to the designated 5-ht1A, 5- HT1B or 5-hydroxytryptamine subtypes.
74
Acute administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat
TL;DR: The cardiovascular effects of 8-OH-DPAT were not prevented by pretreatment with methergoline, methiothepin, pirenperone or cianserine or by 5-HT depletion by means of p-chlorophenylalanine, which suggests that the putative 5- HT receptor is not of a presynaptic type and does not have the pharmacological characteristics of a general5-HT1 receptor.
69
References
Blockade of neuronal tryptamine receptors by metoclopramide
TL;DR: The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves.
144
The influence of tone upon responses of small and large vessels to serotonin.
TL;DR: The study indicates why it is more difficult to demonstrate a similar antagonism when tone is varied by humoral means and produces net dilatation when the bed is constricted.
66
Prazosin and presynaptic alpha-receptors in the cardioaccelerator nerve of the dog
TL;DR: The results indicate that prazosin, like phentolamine and yohimbine, blocks presynaptic α-adrenergic receptors on the cardiac accelerator nerve of the dog but, unlike yohimbe, prazoin does not block these receptors on noradren allergic nerves of rabbit pulmonary artery.
49
Release of Noradrenaline from the Dog Heart In Situ after Intravenous and Intracoronary Administration of 5‐Hydroxytryptamine
TL;DR: It is concluded that the cardiac stimulatory effects of 5-HT are mediated by NA; this NA is mainly derived from sympathetic nerve endings by intra-neuronal exchange for 4H-5-HT.
41