Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer.

TL;DR: In future, determining the driving factors behind ICB resistance by tools of precision medicine may maximize clinical benefits from ICBs and open new directions for overcomingICB resistance.

TL;DR: In this article, a method comprising of determining cytolytic activity in a tumor from the subject, determining genetic alterations associated with the activity in the tumor, and administering an immunotherapeutic agent to the subject if the activity is detected, and a genetic alteration associated with induction or suppression of the activity was identified.

TL;DR: The main mechanisms of drug resistance clinicians and investigators are dealing with during the exploitation and exploration of the anti-tumour effects of drugs in PDAC treatment are summarized and Corresponding measures to overcome these limitations are discussed.

TL;DR: In this article , an integrated bioinformatics approach was used to identify prognostic markers correlated with PLAU expression using different transcriptomics, proteomics, and clinical data sets.

TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.

TL;DR: Antibody-mediated blockade of PD-L1 induced durable tumor regression and prolonged stabilization of disease in patients with advanced cancers, including non-small-cell lung cancer, melanoma, and renal-cell cancer.

TL;DR: FOLFIRINOX was associated with a survival advantage and had increased toxicity as compared with gemcitabine, and is an option for the treatment of patients with metastatic pancreatic cancer and good performance status.

TL;DR: The use of sipuleucel-T prolonged overall survival among men with metastatic castration-resistant prostate cancer and immune responses to the immunizing antigen were observed in patients who received sipuleUcel- T.