Etiology-dependent molecular mechanisms in human hepatocarcinogenesis

TL;DR: H‐HCA showed a combination of alterations related to HNF1α inactivation that may cooperate to promote tumor development, and Interestingly, mTOR appears as a potential new attractive therapeutic target for treatment of this group of HCAs.

TL;DR: Both univariate and multivariate analyses revealed that MACC1 expression was associated with overall survival (OS) and disease-free survival (DFS) and stratified analysis showed that tumour-node-metastasis (TNM) stage I patients with highMACC1 levels had shorter OS and DFS than those with low MACC 1.

TL;DR: It is shown that 22 miRNAs are often amplified or deleted in HCC, and microRNA‐151, a frequently amplified miRNA on 8q24.3, is correlated with intrahepatic metastasis of HCC.

TL;DR: An important role for BOP1 is underline in HCC invasiveness and metastasis potentials through inducing EMT and promoting actin cytoskeleton remodeling through inducing actin stress fiber assembly and RhoA activation.

TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.

TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.

TL;DR: A method that assigns a score to each gene on the basis of change in gene expression relative to the standard deviation of repeated measurements is described, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation.

TL;DR: A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve current concepts for screening and treatment of this disease.