Etiology-dependent molecular mechanisms in human hepatocarcinogenesis

TL;DR: EEFSEC knockdown significantly inhibits proliferation, migration, and invasion of prostate cancer cells in vitro, associated with cell cycle arrest and down-regulation of C-myc, suggesting a potential therapeutic target for prostate cancer treatment.

TL;DR: A simple and inexpensive liver‐specific transgenic approach was developed, in which a hydrodynamics‐based transfection (HT) method was coupled with the Sleeping Beauty transposase system, to elucidate the cooperation between oncogenic signaling pathways and aid in designing molecular therapy to target altered pathways.

TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.

TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.

TL;DR: A method that assigns a score to each gene on the basis of change in gene expression relative to the standard deviation of repeated measurements is described, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation.

TL;DR: A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve current concepts for screening and treatment of this disease.