Estimation of toxic hazard—A decision tree approach

TL;DR: Great emphasis needs to be placed on i) the selection of training and test sets of chemicals to enable both internal and external validation of models to be undertaken for more accurate assessment of model predictivity and ii) the use of recently developed techniques for characterising structure–activity landscapes.

TL;DR: Given its strong technical foundation, inclusion of quality-reviewed data, and provision of tools designed to facilitate communication between users, COSMOS NG is a first step towards building a toxicological knowledge hub leveraging many public data systems for chemical safety evaluation.

TL;DR: Based on extensive experience on filter extractables study, a practical and science-based approach for determination of extractables/leachables from single-use systems used in biomanufacturing has been developed as mentioned in this paper.

TL;DR: This chapter, after a general overview of traditional and well-known approaches, gives a detailed presentation of the latter more recent support tools freely available in the public domain.

TL;DR: An updated account is presented of the activities or the Expert Panel of the Flavor and Extract Manufacturers' Association for establishing the generally recognized as safe (GRAS) status of flavouring substances in accordance with the Food Additives Amendment to the US Federal Food, Drug, and Cosmetic Act.