Journal Article10.1016/S0015-6264(76)80522-6
Estimation of toxic hazard—A decision tree approach
G.M. Cramer,R.A. Ford,R.L. Hall +2 more
1.3K
TL;DR: A procedure for making a significant part of this process rational, public and explicit is proposed, which consists of a ‘decision tree’ of 33 questions, each answered ‘yes’ or ‘no’, and rests heavily on known data on metabolism and toxicity.
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About: This article is published in Food and Cosmetics Toxicology. The article was published on 01 Jan 1976.
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Citations
An overview of current practices for regulatory risk assessment with lessons learnt from cosmetics in the European Union
TL;DR: In this paper, an overview of established and more recently introduced methods for hazard assessment and risk characterisation for human health, in particular in the context of the EU Cosmetics Regulation (EC No 1223/2009) as well as the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation (EC 1907/2006).
19
Utilizing relative potency factors (RPF) and threshold of toxicological concern (TTC) concepts to assess hazard and human risk assessment profiles of environmental metabolites: A case study
TL;DR: The toxicology programme developed for sulfoxaflor and its metabolites is described, and how it might be used to address similar future challenges aimed at determining the relevance of the metabolites from a human hazard and risk perspective is described.
19
Regulatory Forum Opinion Piece*: Supporting the Need for International Harmonization of Safety Assessments for Food Flavoring Substances
TL;DR: The current regulatory requirements in Europe, the United States, and Japan for flavoring substances (FSs) used in foods are presented and significant differences relevant to the international standardization for safety assessments are pointed out.
19
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
Jenny Ho,Davide Sciuscio,Ulrike Kogel,Bjoern Titz,Patrice Leroy,Gregory Vuillaume,Marja Talikka,Elyette Martin,Pavel Pospisil,Stefan Lebrun,Wenhao Xia,Tom Lee,Yun Xuan Chng,Blaine Phillips,Emilija Veljkovic,Emmanuel Guedj,Yang Xiang,Nikolai V. Ivanov,Manuel C. Peitsch,Julia Hoeng,Patrick Vanscheeuwijck +20 more
TL;DR: The results indicated that the inhalation of an e-liquid containing the mixture of FGRs caused very minimal local and systemic toxic effects, and there were no remarkable clinical (in-life) observations in flavored e- liquid-exposed rats.
References
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Registry of Toxic Effects of Chemical Substances
Richard J. Lewis,Rodger L. Tatken +1 more
- 01 Nov 1986
1K
Criteria employed by the expert panel of FEMA for the GRAS evaluation of flavouring substances.
B.L. Oser,R.L. Hall +1 more
TL;DR: An updated account is presented of the activities or the Expert Panel of the Flavor and Extract Manufacturers' Association for establishing the generally recognized as safe (GRAS) status of flavouring substances in accordance with the Food Additives Amendment to the US Federal Food, Drug, and Cosmetic Act.
48
•Book
Lists of volatile compounds in food.
S. van Straten,Flora de Vrijer,Centraal Instituut voor Voedingsondeizoek Tno +2 more
- 01 Jan 1973
19
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