Journal Article10.1016/S0015-6264(76)80522-6
Estimation of toxic hazard—A decision tree approach
G.M. Cramer,R.A. Ford,R.L. Hall +2 more
1.3K
TL;DR: A procedure for making a significant part of this process rational, public and explicit is proposed, which consists of a ‘decision tree’ of 33 questions, each answered ‘yes’ or ‘no’, and rests heavily on known data on metabolism and toxicity.
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About: This article is published in Food and Cosmetics Toxicology. The article was published on 01 Jan 1976.
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Citations
RIFM fragrance ingredient safety assessment, 4-hydroxy-3-methyloctanoic acid lactone, CAS Registry Number 39212-23-2.
A.M. Api,F. Belmonte,D. Belsito,S. Biserta,D. Botelho,Magnus Bruze,G. A. Burton,J. Buschmann,M. A. Cancellieri,Maria Lúcia Zaidan Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,S. Gadhia,L. Jones,K. Joshi,A. Lapczynski,M. Lavelle,D. C. Liebler,M. Na,D. O'Brien,A. Patel,T. M. Penning,G. Ritacco,F. Rodriguez-Ropero,J. Romine,N. Sadekar,D. Salvito,T. W. Schultz,F. Siddiqi,I. G. Sipes,G. Sullivan,Y. Thakkar,Y. Tokura,S. Tsang +35 more
1
RIFM fragrance ingredient safety assessment, dihydro-α-terpineol, CAS Registry Number 498-81-7.
A.M. Api,D. Belsito,S.P. Bhatia,D. Botelho,D. Browne,Magnus Bruze,A. Burton,J. Buschmann,Peter Calow,Maria Lúcia Zaidan Dagli,M. Date,W. Dekant,C. Deodhar,Allison D. Fryer,K. Joshi,L Kromidas,S. La Cava,J F Lalko,A. Lapczynski,D. C. Liebler,Yoshiki Miyachi,D. O'Brien,R. Parakhia,A. Patel,T. M. Penning,Valerie T. Politano,G. Ritacco,J. Romine,D. Salvito,T. W. Schultz,Jie Shen,I. G. Sipes,Y. Thakkar,Yoshiki Tokura,S. Tsang,J. Wahler,B Wall,D K Wilcox +37 more
TL;DR: RIFM fragrance ingredient safety assessment, dihydro-a-terpineol, CAS Registry Number 498-81-7 A.M.
1
RIFM fragrance ingredient safety assessment, 3,7-dimethyloct-1-en-3-ol, CAS Registry Number 18479-49-7.
A.M. Api,Donald V. Belsito,Danielle Botelho,Magnus Bruze,G. Allen Burton,Jochen Buschmann,M. A. Cancellieri,M.L. Dagli,M. Date,Wolfgang Dekant,C. Deodhar,Allison D. Fryer,L. Jones,K. Joshi,M. Kumar,A. Lapczynski,M. Lavelle,I-Pang Lee,Daniel C. Liebler,H. Moustakas,M. Na,B. Penning,G. Ritacco,J. Romine,N. Sadekar,Terry W Schultz,D. Selechnik,F. Siddiqi,I. Glenn Sipes,Gerry Sullivan,Y. Thakkar,Yoshinori Tokura +31 more
TL;DR: • 3,7-dimethyloct-1-en-3-ol; a safety assessment based on RIFM's criteria as discussed by the authors , including 7 human health endpoints plus environmental.
1
The impact of artificial intelligence methods on drug design
Szilvia Gyimóthy
- 01 Jan 2023
TL;DR: In this paper , Artificial Intelligence (AI) methods, and in particular machine learning (ML), deep learning (DL), Bayesian nets (BNs), and probabilistic reasoning are offering new tools for computer-assisted drug design (CADD).
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RIFM fragrance ingredient safety assessment, γ-hexalactone, CAS Registry Number 695-06-7.
A.M. Api,Donald V. Belsito,Danielle Botelho,Magnus Bruze,G. Allen Burton,M. A. Cancellieri,Hung-Che Chon,M.L. Dagli,M. Date,Wolfgang Dekant,C. Deodhar,Allison D. Fryer,L. Jones,K. Joshi,M. Kumar,A. Lapczynski,M. Lavelle,I-Pang Lee,Daniel C. Liebler,H. Moustakas,M. Na,B. Penning,G. Ritacco,J. Romine,N. Sadekar,Terry W Schultz,D. Selechnik,F. Siddiqi,I. Glenn Sipes,Gerry Sullivan,Y. Thakkar,Yoshinori Tokura +31 more
TL;DR: • γ-Hexalactone; a safety assessment based on RIFM's criteria as discussed by the authors , based on 7 human health endpoints plus environmental, using target data, read-across, and/or TTC.
1
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Criteria employed by the expert panel of FEMA for the GRAS evaluation of flavouring substances.
B.L. Oser,R.L. Hall +1 more
TL;DR: An updated account is presented of the activities or the Expert Panel of the Flavor and Extract Manufacturers' Association for establishing the generally recognized as safe (GRAS) status of flavouring substances in accordance with the Food Additives Amendment to the US Federal Food, Drug, and Cosmetic Act.
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S. van Straten,Flora de Vrijer,Centraal Instituut voor Voedingsondeizoek Tno +2 more
- 01 Jan 1973
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