Journal Article10.1007/S00198-005-1867-7
Estimates of optimal vitamin D status
Bess Dawson-Hughes,Robert P. Heaney,Michael F. Holick,Paul Lips,Pierre J. Meunier,Reinhold Vieth,Reinhold Vieth +6 more
1.9K
TL;DR: Based on the available evidence, it is believed that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
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Abstract: Vitamin D has captured attention as an important determinant of bone health, but there is no common definition of optimal vitamin D status. Herein, we address the question: What is the optimal circulating level of 25-hydroxyvitamin D [25(OH)D] for the skeleton? The opinions of the authors on the minimum level of serum 25(OH)D that is optimal for fracture prevention varied between 50 and 80 nmol/l. However, for five of the six authors, the minimum desirable 25(OH)D concentration clusters between 70 and 80 nmol/l. The authors recognize that the average older man and woman will need intakes of at least 20 to 25 mcg (800 to 1,000 IU) per day of vitamin D3 to reach a serum 25(OH)D level of 75 nmol/l. Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
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Citations
Vitamin D and Multiple Sclerosis
TL;DR: The results of these studies support a protective effect of vitamin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a Protective effect, how genetic variations modify the effect, and whether vitamin D can influence the course of MS progression.
The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement
Clifford J. Rosen,John S. Adams,Daniel D. Bikle,Dennis M. Black,Marie B. Demay,JoAnn E. Manson,M. Hassan Murad,Christopher S. Kovacs +7 more
TL;DR: More studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.
Vitamin D — Effects on Skeletal and Extraskeletal Health and the Need for Supplementation
TL;DR: There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much vitamin DShould be supplemented.
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Vitamin D and autoimmunity: new aetiological and therapeutic considerations
TL;DR: It seems that vitamin D has crossed the boundaries of calcium metabolism and has become a significant factor in a number of physiological functions, specifically as a biological inhibitor of inflammatory hyperactivity.
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Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
TL;DR: Frail older people confined to institutions may sustain fewer hip and other non-vertebral fractures if given vitamin D with calcium supplements, and there is no evidence of advantage of analogues of vitamin D compared with vitamin D.
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References
Vitamin D3 and calcium to prevent hip fractures in elderly women
Marie Claire Chapuy,Monique E. Arlot,François Duboeuf,Jacqueline Brun,Bridgette Crouzet,Simone Arnaud,Pierre D. Delmas,Pierre J. Meunier +7 more
TL;DR: The effects of supplementation with vitamin D3 (cholecalciferol) and calcium on the frequency of hip fractures and other nonvertebral fractures, identified radiologically, in 3270 healthy ambulatory women are studied.
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Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older
TL;DR: In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures.
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Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women
Marie Claire Chapuy,Monique E. Arlot,François Duboeuf,Jacqueline Brun,Bridgette Crouzet,Simone Arnaud,Pierre D. Delmas,Pierre J. Meunier +7 more
TL;DR: Whether vitamin D, (cholecalciferol) and calcium supplements decrease the frequency of nonvertebral fractures, particularly fractures of the femoral neck, among ambulatory elderly women living in nursing homes is determined.
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Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
TL;DR: Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
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Hypovitaminosis D in Medical Inpatients
Melissa K. Thomas,Donald M. Lloyd-Jones,Ravi Thadhani,Albert C. Shaw,Donald J. Deraska,Barrett T. Kitch,Eleftherios C. Vamvakas,Ian M. Dick,Richard L. Prince,Joel S. Finkelstein +9 more
TL;DR: Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.
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