Journal Article10.1007/S00198-005-1867-7
Estimates of optimal vitamin D status
Bess Dawson-Hughes,Robert P. Heaney,Michael F. Holick,Paul Lips,Pierre J. Meunier,Reinhold Vieth,Reinhold Vieth +6 more
1.9K
TL;DR: Based on the available evidence, it is believed that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
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Abstract: Vitamin D has captured attention as an important determinant of bone health, but there is no common definition of optimal vitamin D status. Herein, we address the question: What is the optimal circulating level of 25-hydroxyvitamin D [25(OH)D] for the skeleton? The opinions of the authors on the minimum level of serum 25(OH)D that is optimal for fracture prevention varied between 50 and 80 nmol/l. However, for five of the six authors, the minimum desirable 25(OH)D concentration clusters between 70 and 80 nmol/l. The authors recognize that the average older man and woman will need intakes of at least 20 to 25 mcg (800 to 1,000 IU) per day of vitamin D3 to reach a serum 25(OH)D level of 75 nmol/l. Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
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Citations
Prevalence and correlates of vitamin D deficiency in US adults
TL;DR: Examination of the prevalence of vitamin D deficiency and its correlates in the US population found that being from a non-white race, not college educated, obese, having low high-density lipoprotein cholesterol, poor health, and no daily milk consumption were all significantly, independently associated with Vitamin D deficiency.
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Vitamin D and Calcium Intake in Relation to Type 2 Diabetes in Women
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TL;DR: The results of this large prospective study suggest a potential beneficial role for both vitamin D and calcium intake in reducing the risk of type 2 diabetes.
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TL;DR: Prevalence of hypovitaminosis D in the general population was alarmingly high during the winter and spring, which warrants action at a population level rather than at a risk group level.
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Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
JoAnn E. Manson,Nancy R. Cook,I-Min Lee,William G. Christen,Shari S. Bassuk,Samia Mora,Heike Gibson,Christine M. Albert,David Gordon,Copeland T,Derek Dagostino,Friedenberg G,Ridge C,Bubes,Edward Giovannucci,Walter C. Willett,Julie E. Buring +16 more
TL;DR: In this article, a randomized, placebo-controlled trial with a two-by-two factorial design, of vitamin D3 (at a dose of 2000 IU per day) and marine n−3 fatty acids (a dose of 1 g per day).
843
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TL;DR: Observations suggest that nonclassical metabolism and response to vitamin D might have a significant role in human physiology beyond skeletal and calcium homeostasis.
References
Vitamin D3 and calcium to prevent hip fractures in elderly women
Marie Claire Chapuy,Monique E. Arlot,François Duboeuf,Jacqueline Brun,Bridgette Crouzet,Simone Arnaud,Pierre D. Delmas,Pierre J. Meunier +7 more
TL;DR: The effects of supplementation with vitamin D3 (cholecalciferol) and calcium on the frequency of hip fractures and other nonvertebral fractures, identified radiologically, in 3270 healthy ambulatory women are studied.
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Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older
TL;DR: In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures.
2.3K
Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women
Marie Claire Chapuy,Monique E. Arlot,François Duboeuf,Jacqueline Brun,Bridgette Crouzet,Simone Arnaud,Pierre D. Delmas,Pierre J. Meunier +7 more
TL;DR: Whether vitamin D, (cholecalciferol) and calcium supplements decrease the frequency of nonvertebral fractures, particularly fractures of the femoral neck, among ambulatory elderly women living in nursing homes is determined.
1.9K
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
TL;DR: Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
1.4K
Hypovitaminosis D in Medical Inpatients
Melissa K. Thomas,Donald M. Lloyd-Jones,Ravi Thadhani,Albert C. Shaw,Donald J. Deraska,Barrett T. Kitch,Eleftherios C. Vamvakas,Ian M. Dick,Richard L. Prince,Joel S. Finkelstein +9 more
TL;DR: Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.
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