Erratum: Eph receptor signalling casts a wide net on cell behaviour
TL;DR: In this article, the axons in parts (b) and (c) of Box 2 should be purple, and not blue, to indicate the co-expression of ephrin-As and EphA receptors.
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Abstract: Nature Rev. Mol. Cell Biol. 6, 462–475 (2005) On page 472 of the article, in Figure 6, q27 on chromosome 3 should indicate the position of EPHB3, and not EPHB6. In addition, the axons in parts (b) and (c) of Box 2 should be purple, and not blue, to indicate the co-expression of ephrin-As and EphA receptors.
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Citations
EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.
Philip D Dunne,Sonali Dasgupta,Jaine K. Blayney,Darragh G. McArt,Keara Redmond,Jessica-Anne Weir,Conor A Bradley,Takehiko Sasazuki,Senji Shirasawa,Tingting Wang,Supriya Srivastava,Chee Wee Ong,Kenneth Arthur,Manuel Salto-Tellez,Richard H. Wilson,Patrick G. Johnston,Sandra Van Schaeybroeck +16 more
TL;DR: Data show that EpHA2 is a poor prognostic marker in stage II/III colorectal cancer, which may be due to its ability to promote cell migration and invasion, providing support for the further investigation of EphA2 as a novel prognostic biomarker and therapeutic target.
131
Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma
TL;DR: Amongst the several proteins analysed, the immunohistochemical expression levels of epithelial growth factor receptor, p53, and matrix metalloproteinases (MMPs) have demonstrated the greatest potential for survival prediction in OSCC, but this review demonstrates that their prognostic relevance is debatable and requires further standardisation.
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Spatial organization of transmembrane receptor signalling
TL;DR: Lipid microdomains have a function in tuning the activity of many transmembrane receptors by positively or negatively affecting receptor clustering and signal transduction.
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Eph receptors and ephrin signaling pathways: a role in bone homeostasis.
TL;DR: The maintenance of bone homeostasis is tightly controlled, and largely dependent upon cellular communication between osteoclasts and osteoblasts, and the coupling of bone resorption to bone formation.
Identification and Functional Analysis of Phosphorylated Tyrosine Residues within EphA2 Receptor Tyrosine Kinase
TL;DR: This work has mapped phosphorylated tyrosines within the intracellular region of EphA2 by a combination of mass spectrometry analysis and phosphopeptide mapping using two-dimensional chromatography in conjunction with site-directed mutagenesis to understand the role of EPhA2 phosphorylation.
125
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Tudorita Tumbar,Géraldine Guasch,Valentina Greco,Cédric Blanpain,William E. Lowry,Michael Rendl,Elaine Fuchs +6 more
TL;DR: It is found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit, and their transcriptional profile is determined, which, when compared to progeny and other SCs, defines the niche.
Mechanisms and functions of eph and ephrin signalling
Klas Kullander,Rüdiger Klein +1 more
TL;DR: The concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell–cell communication.
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The ephrins and eph receptors in neural development
TL;DR: The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps, and may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system.
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β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB
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TL;DR: In this paper, the expression of the EphB2/EphB3 receptors and their ligand ephrin-B1 in colorectal cancer and along the crypt-villus axis was investigated.
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