Epithelialization in Wound Healing: A Comprehensive Review
Irena Pastar,Olivera Stojadinovic,Natalie C. Yin,Horacio Ramirez,Aron G. Nusbaum,Andrew P. Sawaya,Shailee Patel,Laiqua Khalid,R. Isseroff,Marjana Tomic-Canic +9 more
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TL;DR: The pivotal role of keratinocytes in epithelialization is focused on, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing.
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Abstract: Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing. Recent Advances: Discoveries in epidermal stem cells, keratinocyte immune function, and the role of the epidermis as an independent neuroendocrine organ will be reviewed. Novel mechanisms of gene expression regulation important for re-epithelialization, including microRNAs and histone modifications, will also be discussed. Critical Issues: Epithelialization is an essential component of wound healing used as a defining parameter of a successful wound closure. A wound cannot be considered healed in the absence of re-epithelialization. The epithelialization process is impaired in all types o...
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Evaluation of a topical Phenytoin on gingival wound healing
Mehdi Honarparvar
- 01 Jun 2018
TL;DR: Wound healing is very important and should always address the needs of the patient, promote normal healing and prevent complications, so clear instructions are necessary on what to do, when to do it and what should be raised as a concern.
Investigating Epidermal Interactions Through an In Vivo Cutaneous Wound-Healing Assay.
TL;DR: This protocol details an in vivo wound healing assay to study the intersection of cellular, molecular, and systemic effector pathways in wound healing to efficiently explore the role of certain proteins in the wound healing process through the generation of tissue-specific deficient mice.
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