Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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About: This article is published in Cell. The article was published on 25 Nov 2009. and is currently open access. The article focuses on the topics: Epithelial–mesenchymal transition & SNAI1.
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Citations
Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells
Maria Letizia Taddei,Elisa Giannoni,Andrea Morandi,Luigi Ippolito,Matteo Ramazzotti,Maurizio Callari,Paolo Gandellini,Paola Chiarugi +7 more
TL;DR: The results demonstrate that MAT programme in melanoma is characterised by increased stemness and clonogenic features of cancer cells, thus sustaining tumour progression, and suggest that stemness is not an exclusive feature of cells undergoing EMT, but more generally is associated with an increase in cellular plasticity ofcancer cells.
Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal–Epithelial Transition in Head and Neck Cancer Cells
Cheng-Chi Chang,Wen Hao Hsu,Chen Chien Wang,Chun Hung Chou,Mark Yen-Ping Kuo,Been-Ren Lin,Szu-Ta Chen,Shyh Kuan Tai,Min-Liang Kuo,Muh Hwa Yang +9 more
TL;DR: In head and neck squamous cell carcinoma (HNSCC), CTGF promotes the MET and reduces invasiveness and it is found that CTGF enhances the stem-like properties of HNSCC cells and increases the expression of multiple pluripotency genes.
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Tumor-Initiating and -Propagating Cells: Cells That We Would Like to Identify and Control
TL;DR: Insight into the mechanisms by which pluripotency transcription factors, polycomb repressive complexes and microRNA balance selfrenewal and differentiation will be essential for the understanding of both embryonic differentiation and human carcinogenesis and for the development of new treatment strategies.
98
Fibroblast growth factor 2 accelerates the epithelial–mesenchymal transition in keratinocytes during wound healing process
TL;DR: FGF2 treatment of wounds could promote keratinocyte EMT, accelerating wound closure, according to in vitro examination of keratinocytes, but that FGF2 might promote EMT in combination with TGFβ1.
MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway
Xiaoyun Chen,Wei Xiao,Weirong Chen,Xialin Liu,Mingxing Wu,Qu Bo,Yan Luo,Shaobi Ye,Yihai Cao,Yizhi Liu +9 more
TL;DR: In vitro and in vivo evidence is provided that Jagged-1/Notch signaling is activated in TGFβ2-stimulated EMT, and blockade of Notch signaling can reverse lens epithelial cells (LECs) EMT and lens fibrosis.
References
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
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Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
Amparo Cano,Mirna Perez-Moreno,Isabel Rodrigo,Annamaria Locascio,Maria Blanco,Marta G. del Barrio,Francisco Portillo,M. Angela Nieto +7 more
TL;DR: It is shown that mouse Snail is a strong repressor of transcription of the E-cadherin gene, opening up new avenues for the design of specific anti-invasive drugs.
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TGFβ in Cancer
TL;DR: The mechanistic basis and clinical relevance of TGFbeta's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway.
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