Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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About: This article is published in Cell. The article was published on 25 Nov 2009. and is currently open access. The article focuses on the topics: Epithelial–mesenchymal transition & SNAI1.
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Citations
Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT).
TL;DR: The global switches in splicing associated with the EMT add an important additional layer of post-transcriptional control that works in harmony with transcriptional and epigenetic regulation to effect complex changes in cell shape, polarity, and behavior that mediate transitions between epithelial and mesenchymal cell states.
142
The perivascular origin of pathological fibroblasts
Selene Di Carlo,Lucie Peduto +1 more
TL;DR: Recent insights gained from the use of lineage tracing approaches in several organs point toward specific subsets of tissue-resident mesenchymal cells, mainly localized in a perivascular position, as the major source for collagen-producing cells after injury.
Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition.
Yueqin Yang,Juw Won Park,Thomas W. Bebee,Claude C. Warzecha,Yang Guo,Xuequn Shang,Yi Xing,Russ P. Carstens +7 more
TL;DR: The broad role of posttranscriptional regulation during the EMT is highlighted and the important role of combinatorial regulation by different splicing factors to fine tune gene expression programs during these physiological and developmental transitions is highlighted.
Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential.
Jana Knezevic,Adam D. Pfefferle,Ivana Petrovic,Stephanie B. Greene,Charles M. Perou,Jeffrey M. Rosen +5 more
TL;DR: Investigating the role of known EMT regulators, miR-200 family of microRNAs in controlling the epithelial state, stem-like properties and therapeutic response in an in vivo primary, syngeneic p53null claudin-low tumor model suggests miR200c expression offers a potential therapeutic application to disrupt the EMT program on multiple fronts in this mesenchymal tumor subtype by altering tumor growth, chemosensitivity and metastatic potential in vivo.
141
Mitochondrial membrane anchored photosensitive nano-device for lipid hydroperoxides burst and inducing ferroptosis to surmount therapy-resistant cancer.
Mangmang Sang,Renjie Luo,Yidan Bai,Jun Dou,Zhang Zhongtao,Fulei Liu,Feng Feng,Jian Xu,Wenyuan Liu +8 more
TL;DR: In vivo pharmacodynamic test results showed that this nanodevice with small particle size and high cytotoxicity increased Srfn circulation and shortened the period of epithelial cancer treatment, having great potential in the treatment of therapy-resistant epithelial cell carcinomas.
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References
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
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Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
Amparo Cano,Mirna Perez-Moreno,Isabel Rodrigo,Annamaria Locascio,Maria Blanco,Marta G. del Barrio,Francisco Portillo,M. Angela Nieto +7 more
TL;DR: It is shown that mouse Snail is a strong repressor of transcription of the E-cadherin gene, opening up new avenues for the design of specific anti-invasive drugs.
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TGFβ in Cancer
TL;DR: The mechanistic basis and clinical relevance of TGFbeta's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway.
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