Journal Article10.1038/NSMB.2489
Epigenetic programming and reprogramming during development
Irene Cantone,Amanda G. Fisher +1 more
440
TL;DR: Current models of epigenetic erasure are summarized, the various enzymes and mechanisms that may operate in cellular reprogramming are discussed, and some of the recent advances in understanding how epigenetic remodeling contributes to conversion of cell fate are reviewed.
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Abstract: Cell identity is determined by specific gene expression patterns that are conveyed by interactions between transcription factors and DNA in the context of chromatin. In development, epigenetic modifiers are thought to stabilize gene expression and ensure that patterns of DNA methylation and histone modification are reinstated in cells as they divide. Global erasure of epigenetic marks occurs naturally at two stages in the mammalian life cycle, but it can also be artificially engineered using a variety of reprogramming strategies. Here we review some of the recent advances in understanding how epigenetic remodeling contributes to conversion of cell fate in vivo and in vitro. We summarize current models of epigenetic erasure and discuss the various enzymes and mechanisms that may operate in cellular reprogramming.
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Citations
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells
Fan Guo,Liying Yan,Liying Yan,Hongshan Guo,Lin Li,Boqiang Hu,Yangyu Zhao,Yangyu Zhao,Jun Yong,Yuqiong Hu,Xiaoye Wang,Xiaoye Wang,Yuan Wei,Yuan Wei,Wei Wang,Wei Wang,Rong Li,Rong Li,Jie Yan,Jie Yan,Xu Zhi,Xu Zhi,Yan Zhang,Yan Zhang,Hongyan Jin,Hongyan Jin,Wenxin Zhang,Wenxin Zhang,Yu Hou,Ping Zhu,Jingyun Li,Ling Zhang,Sirui Liu,Yixin Ren,Yixin Ren,Xiaohui Zhu,Xiaohui Zhu,Lu Wen,Lu Wen,Yi Qin Gao,Fuchou Tang,Jie Qiao +41 more
TL;DR: The transcriptome of human primordial germ cells (PGCs) from the migrating stage to the gonadal stage is analyzed at single-cell and single-base resolutions and paves the way toward deciphering the complex epigenetic reprogramming of the germline with the aim of restoring totipotency in fertilized oocytes.
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