Epidermal sphingomyelins are precursors for selected stratum corneum ceramides
Yoshikazu Uchida,Mariko Hara,Hiroyuki Nishio,Ellen Sidransky,Shintaro Inoue,Fujio Otsuka,Akemi Suzuki,Peter M. Elias,Walter M. Holleran,Sumiko Hamanaka +9 more
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TL;DR: Two epidermal SM, SM-1 and SM-3, are important precursors of two corresponding Cer in mammalian SC, that is, Cer 2 and Cer 5, but other Cerspecies, including the omega-hydroxy Cer species, do not derive from SM.
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About: This article is published in Journal of Lipid Research. The article was published on 01 Dec 2000. and is currently open access.
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Citations
Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol
TL;DR: Up-regulation of PS may suggest that CBD inhibits their oxidative modification, while changes in the content of PE and SM may indicate a role of CBD in promoting autophagy and improving the status of the transepidermal barrier.
By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans.
Tzu Kai Lin,Mao-Qiang Man,Katrina Abuabara,Joan S. Wakefield,Hamm Ming Sheu,Jui Chen Tsai,Chih Hung Lee,Peter M. Elias +7 more
TL;DR: Pigmentation yields a reduced propensity to develop inflammation, consistent with the hypothesis that dark pigmentation evolved in ancestral humans to provide a suite of barrier‐linked benefits that now include resistance to inflammation.
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
Chrystelle Bonnart,Céline Deraison,Matthieu Lacroix,Yoshikazu Uchida,Céline Besson,Aurélie Robin,Anaïs Briot,Marie Gonthier,Laurence Lamant,Pierre Dubus,Bernard Monsarrat,Alain Hovnanian +11 more
TL;DR: This work identifies elastase 2 (ELA2) as a major new epidermal protease involved in essential pathways for skin barrier function and designate ELA2 as amajor protease driving the pathogenesis of NS.
Extracellular pH Controls NHE1 Expression in Epidermis and Keratinocytes: Implications for Barrier Repair
Jean-Pierre Hachem,Jean-Pierre Hachem,Jean-Pierre Hachem,Martin J. Behne,Martin J. Behne,Ida Aronchik,Ida Aronchik,Marianne Demerjian,Marianne Demerjian,Kenneth R. Feingold,Kenneth R. Feingold,Peter M. Elias,Peter M. Elias,Theodora M. Mauro,Theodora M. Mauro +14 more
TL;DR: The data suggest that the keratinocyte NHE1 is regulated by extracellular pH, suggesting that the epidermis must re-establish its epidermal barrier after acute barrier perturbations, and acidifying SC pH overrode the effects of barrier break in regulating N HE1 expression.
Hereditary Sensory Neuropathy Type 1 Mutations Confer Dominant Negative Effects on Serine Palmitoyltransferase, Critical for Sphingolipid Synthesis
K Bejaoui,Y Uchida,S Yasuda,M Ho,M Nishijima,RH Brown,WM Holleran,K Hanada +7 more
TL;DR: HSN1 mutations in SPTLC1 gene confer dominant negative effects on serine palmitoyltransferase, impairing sphingolipid synthesis, and reducing SPT activity, despite normal subunit levels, indicating a pathogenic mechanism for hereditary sensory neuropathy type 1.
References
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
51.6K
Rapid method of total lipid extraction and purification
E G Bligh,Dyer W.J.A. +1 more
- 01 Jan 1959
48.8K
Decreased level of ceramides in stratum corneum of atopic dermatitis : an etiologic factor in atopic dry skin ?
TL;DR: Findings suggest that an insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin.
1K
Regulation of ceramide production and apoptosis
Richard Kolesnick,Martin Krönke +1 more
TL;DR: The pathways of ceramide generation and the interaction of Ceramide with caspases and other apoptotic signaling cascades are discussed.
845
Ceramides of pig epidermis: structure determination
TL;DR: Seven distinguishable groups of ceramides have been isolated from pig epidermis and identified and apparently form a large proportion of the intercellular lipid lamellae in the epidermal stratum corneum, which are thought to constitute the barrier to water loss.
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