Epidermal sphingomyelins are precursors for selected stratum corneum ceramides
Yoshikazu Uchida,Mariko Hara,Hiroyuki Nishio,Ellen Sidransky,Shintaro Inoue,Fujio Otsuka,Akemi Suzuki,Peter M. Elias,Walter M. Holleran,Sumiko Hamanaka +9 more
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TL;DR: Two epidermal SM, SM-1 and SM-3, are important precursors of two corresponding Cer in mammalian SC, that is, Cer 2 and Cer 5, but other Cerspecies, including the omega-hydroxy Cer species, do not derive from SM.
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About: This article is published in Journal of Lipid Research. The article was published on 01 Dec 2000. and is currently open access.
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Citations
Lipidomic platform for structural identification of skin ceramides with α-hydroxyacyl chains
Zhexue Wu,Jong Cheol Shon,Doohyun Lee,Kab-Tae Park,Chang Seo Park,Tae-Ho Lee,Hye Suk Lee,Kwang-Hyeon Liu +7 more
TL;DR: Tandem mass Spectrometry analysis of A-type ceramides using chip-based direct infusion nanoelectrospray-mass spectrometry showed the characteristic fragmentation pattern of both acyl and sphingoid units, which can be applied for structural identification of ceramide.
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Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy
Alexandra C. Kendall,Suzanne M. Pilkington,Jonathan R Wray,Victoria L. Newton,Christopher E.M. Griffiths,Mike Bell,Rachel E.B. Watson,Anna Nicolaou +7 more
TL;DR: In this article , the effect of hormone replacement therapy (HRT) on epidermal changes that are alleviated by menopause was investigated, and it was found that oestrogen may have a role in keratinocyte ceramide metabolism.
Assessment of the skin barrier function in the reconstructed human epidermis using a multimodal approach at molecular, tissue and functional levels.
Joudi Bakar,Rime Michael-Jubeli,Rindala El Khoury,Sabrina Hamla,Ali Assi,Arlette Baillet-Guffroy,Ali Tfayli +6 more
TL;DR: In this article, a link between the barrier function and the structure and composition of the stratum corneum using several complementary techniques was established, and the results demonstrated that the caffeine penetration decreased along the differentiation process.
10
Photoprotective effects of sphingomyelin-containing milk phospholipids in ultraviolet B-irradiated hairless mice by suppressing NF-κB expression.
TL;DR: Oral administration of milk phospholipids improves skin health through a synergistic effect on photoprotective activity and downregulation of protein expression of nuclear factor kappa-B (NF-κB) and phosphorylated IκB-α (inhibitor of κB α).
Comprehensive characterization and simultaneous analysis of overall lipids in reconstructed human epidermis using NPLC/HR-MSn: 1-O-E (EO) Cer, a new ceramide subclass
Ali Assi,Joudi Bakar,D. Libong,Elie Sarkees,Audrey Solgadi,Arlette Baillet-Guffroy,Rime Michael-Jubeli,Ali Tfayli +7 more
TL;DR: The lipidomic approach offers a direct access to epidermis biomarkers, and a new subclass of ceramides, 1-O-Acyl Omega-linoleoyloxy ceramide, has been highlighted, which can contribute to the skin barrier.
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