Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study.

Abstract: Additional file 10: Figure S9. ARDS mediates about 13.36% effect of OSI trajectory index on ICU mortality. OSI: oxygen saturation index.

Abstract: Additional file 12: Figure S11. The predictive marginal effect of ARDS on ICU mortality in patients with or without ARDS. ARDS: acute respiratory distress syndrome; OSI: oxygen saturation index.

TL;DR: This study picked up hub genes of ARDS related to autophagy and metabolism and clustered ARDS patients into different molecular phenotypes and immunophenotypes, providing insights into the precision medicine of treating patients with ARDS.

Abstract: Additional file 2: Figure S2. The DAGs showed covariates of the association between the OSI-based trajectory phenotypes and ICU mortality. The demographics included age, gender and ethnicity. The respiratory comorbidities included ARDS, COPD. Other comorbidities included CKD, AKI, malignancy, HF and diabetes. PaCO2 and hemoglobin were included in the laboratory events. The ventilation parameters included PEEP, plateau pressure, tidal volume, OSI at baseline and the treatment included dialysis, NMBAs and vasopressor therapy. DAGs: Directed acyclic graphs; BMI: body mass index; OSI: oxygen saturation index; PEEP: positive end expiratory pressure; NMBAs: neuromuscular blockades; APS-III score: acute physiology score III; ARDS: acute respiratory distress syndrome; AKI: acute kidney injury; COPD: chronic obstructive pulmonary disease; HF: heart failure; CKD: chronic kidney disease.

TL;DR: An update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008 is provided.

TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.

TL;DR: A consensus committee of 68 international experts representing 30 international organizations was convened in 2008 to provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock".

TL;DR: Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS.