Eosinophils in mucosal immune responses
J Travers,M.E. Rothenberg +1 more
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TL;DR: The basic biology of eosinophils is reviewed and new emerging concepts about their role in mucosal immune homeostasis, particularly maintenance of intestinal IgA are described.
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About: This article is published in Mucosal Immunology. The article was published on 25 Mar 2015. and is currently open access. The article focuses on the topics: Acquired immune system & Immune system.
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Citations
Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline
Fernando Holguin,Juan Carlos Cardet,Kian Fan Chung,Sarah Diver,Diogenes S. Ferreira,Diogenes S. Ferreira,Anne M. Fitzpatrick,Mina Gaga,Liz Kellermeyer,Sandhya Khurana,Shandra L Knight,Vanessa M. McDonald,Rebecca L. Morgan,Victor E. Ortega,David Rigau,Padmaja Subbarao,Thomy Tonia,Ian M. Adcock,Eugene R. Bleecker,Christopher E. Brightling,Louis-Philippe Boulet,Michael D. Cabana,Mario Castro,Pascal Chanez,Adnan Custovic,Ratko Djukanovic,Urs Frey,Betty Frankemölle,Peter G. Gibson,Dominique Hamerlijnck,Nizar N. Jarjour,Satoshi Konno,Huahao Shen,Cathy Vitary,Andrew Bush +34 more
TL;DR: Clinical recommendations for the management of severe asthma are provided and the use of novel therapies for severe asthma, specifically biologicals for type 2 high asthma, and antimuscarinic agents and macrolides, as well as on biomarkers for predicting treatment response are made.
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Lung-resident eosinophils represent a distinct regulatory eosinophil subset
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Eosinophil-derived neurotoxin acts as an alarmin to activate TLR2-MyD88 signal pathway in dendritic cells and enhance Th2 immune responses
De Yang,Qian Chen,Shao-Bo Su,Ping Zhang,Rachel R. Caspi,Suzanne M. Micchalek,Helene R. Rosenberg,Joost J. Oppenheim +7 more
TL;DR: In this article, an eosinophil-derived neurotoxin (EDN) was shown to activate myeloid dendritic cells by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway, thus establishing EDN as an endogenous ligand of TLR2.
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Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment
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Eosinophils: The unsung heroes in cancer?
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TL;DR: Increasing evidence in experimental models indicates that activation/recruitment of eosinophils could represent a new therapeutic strategy for certain tumors (e.g., melanoma) and many unanswered questions should be addressed before it is understood whether eos inophils are an ally, adversary or neutral bystanders in different types of human cancers.
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References
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Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5–induced eosinophil development
Netali Ben Baruch-Morgenstern,Dana Shik,Itay Moshkovits,Michal Itan,Danielle Karo-Atar,Carine Bouffi,Patricia C. Fulkerson,Diana Rashkovan,Steffen Jung,Marc E. Rothenberg,Ariel Munitz +10 more
TL;DR: Collectively, these data uncover an intrinsic, self-limiting pathway regulating IL-5–induced expansion of eosinophils, which has broad implications for eOSinophil-associated diseases.
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The relationship between eosinophilia and airway remodelling in mild asthma.
Susan J. Wilson,Helen M. Rigden,Jonathan Ward,Michel Laviolette,Nizar N. Jarjour,Ratko Djukanovic +5 more
TL;DR: Eosinophilia is a marker of corticosteroid responsiveness and risk of exacerbation in asthma; although it has been linked to submucosal matrix deposition, its relationship with other features of airway remodelling is less clear.
Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariea and schistosomes
TL;DR: Significantly higher ECP levels in chronic hyperreactive onchodermatitis (sowda) versus generalized onchocerciasis seem to reflect an augmented degree of antigenic stimulation, eosinophil activation and eos inophil turnover rates, indicating a more active mechanism of parasite clearance in sowda patients.
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Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis
Joanne C. Masterson,Eóin N. McNamee,Lindsay Hosford,Kelley E. Capocelli,Kelley E. Capocelli,Joseph Ruybal,Sophie Fillon,Alfred D. Doyle,Holger K. Eltzschig,Anil K. Rustgi,Cheryl A. Protheroe,Nancy A. Lee,James J. Lee,Glenn T. Furuta +13 more
TL;DR: A mouse model that closely resembles EoE by utilising oxazolone haptenation in mice with transgenic overexpression of an eosinophil poietic and survival factor (interleukin (IL)-5) in resident squamous oesophageal epithelia is developed.