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Enzymes : a practical introduction to structure, mechanism, and data analysis
Robert A. Copeland
- 01 Jan 2000
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TL;DR: This paper presents a meta-analyses of Enzyme Reactions with Multiple Substrates with the aim of determining the mechanism behind Cooperativity in Enzyme Catalysis and its role in enzymology.
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Abstract: A Brief History of Enzymology. Chemical Bonds and Reactions in Biochemistry. Structural Components of Enzymes. Protein-Ligand Binding Equilibria. Kinetics of Single-Substrate Enzyme Reactions. Chemical Mechanisms in Enzyme Catalysis. Experimental Measures of Enzyme Activity. Reversible Inhibitors. Tight Binding Inhibitors. Time-Dependent Inhibition. Enzyme Reactions with Multiple Substrates. Cooperativity in Enzyme Catalysis. Appendices. Index.
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Molecular dynamics simulation of the gGAPDH–NAD+ complex from Trypanosoma cruzi
TL;DR: In this paper, a 50ns molecular dynamics simulation was used to study the homotetramer of the enzyme glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) complexes, from Trypanosoma cruzi, with nicotinamide adenine dinucleotide (NAD+) cofactors in aqueous solution.
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In Vitro and In Planta Cyclization of Target Peptides Using an Asparaginyl Endopeptidase from Oldenlandia affinis.
TL;DR: This chapter describes how to utilize a cyclizing AEP (OaAEP1b) to produce backbone-cyclized peptides both in planta and in vitro.
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Slow-Onset, Potent Inhibition of Mandelate Racemase by 2-Formylphenylboronic Acid. An Unexpected Adduct Clasps the Catalytic Machinery.
Colin D. Douglas,Lia Grandinetti,Nicole M. Easton,Oliver P Kuehm,Joshua A Hayden,Meghan C Hamilton,Martin St. Maurice,Stephen L. Bearne +7 more
TL;DR: In this paper, 2-formylphenylboronic acid (2-FPBA) was shown to be a potent reversible, slow-onset inhibitor of mandelate racemase.
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Enzymatic Treatment of Polyamide 6.6 Fibres
Carla Silva
- 01 Jul 2009
TL;DR: Research objectives and thesis outline, Monitoring biotransformations in polyamide 6.6 fibres...............................
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Bisphosphoramidate derivatives: synthesis, crystal structure, anti-cholinesterase activity, insecticide potency and QSAR analysis
Khodayar Gholivand,Ali Asghar Ebrahimi Valmoozi,Mina Salahi,Fatemeh Taghipour,Elham Torabi,Saied Ghadimi,Mahboobeh Sharifi,Mohammad Ghadamyari +7 more
TL;DR: In this paper, a series of temephos derivatives with the general structure of P(O)NH-X-NHP (O) (1-22) were synthesized and characterized by 31P, 13C, 1H NMR and FT-IR spectral techniques.
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