Reference Entry10.1002/9780470015902.A0000861.PUB2
Enzyme Activity: Control
Shorena Nadaraia,George J. Yohrling,George C.T. Jiang,John M. Flanagan,Kent E. Vrana +4 more
- 19 Apr 2001
2
TL;DR: Enzymes are the metabolic catalysts that affect a multitude of physiological processes and responses and are therefore essential in maintaining the steady state of all organisms.
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Abstract: Enzymes are the metabolic catalysts that affect a multitude of physiological processes and responses. Tight control of enzyme activity is therefore essential in maintaining the steady state of all organisms.
Keywords:
feedback inhibition;
phosphorylation;
allosteric regulation;
covalent modification;
proenzymes
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Citations
CRYPTOCHROMES promote daily protein homeostasis
David C S Wong,Estere Seinkmane,Aiwei Zeng,Alessandra Stangherlin,Nina M Rzechorzek,Andrew D. Beale,Jason Day,Martin Reed,Sew Y. Peak-Chew,Christine T. Styles,Rachel S. Edgar,Marrit Putker,John S. O’Neill +12 more
TL;DR: In this paper, the authors used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions, and found that the extent of temporal variation within either genotype was much smaller than overall differences in proteome composition between WT and CCRYdeficient cells, suggesting that the various transcriptional and posttranslational functions of CRY proteins ultimately act to maintain protein and osmotic homeostasis against daily perturbation.
14
CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis
David C S Wong,Estere Seinkmane,Alessandra Stangherlin,Aiwei Zeng,Nina M Rzechorzek,Andrew D. Beale,Jason Day,Martin Reed,Sew Y. Peak-Chew,Marrit Putker,John S. O’Neill +10 more
TL;DR: It is suggested that CRY ultimately functions to suppress, rather than generate, daily rhythms in cellular protein abundance, thereby maintaining protein and osmotic homeostasis.
12
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Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration.
Siddharth Kaul,Arthi Kanthasamy,Masashi Kitazawa,Vellareddy Anantharam,Anumantha G. Kanthasamy +4 more
TL;DR: It is demonstrated for the first time that MPP+‐induced oxidative stress proteolytically activates PKCδ in a caspase‐3‐dependent manner to induce apoptosis and up‐regulate the casp enzyme cascade in dopaminergic neuronal cells.
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