Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
Sandy Leung-Kuen Au,Carmen Chak-Lui Wong,Joyce Man-Fong Lee,Dorothy Ngo-Yin Fan,Felice Ho-Ching Tsang,Irene Oi-Lin Ng,Chun-Ming Wong +6 more
TL;DR: The findings suggest that EZH2 exerts its prometastatic function by way of epigenetic silencing of multiple tumor suppressor miRNAs in modulating cell motility and metastasis‐related pathways.
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About: This article is published in Hepatology. The article was published on 01 Aug 2012. and is currently open access. The article focuses on the topics: Gene silencing & EZH2.
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Citations
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
Mengnuo Chen,Lai Wei,Cheuk-Ting Law,Felice Ho-Ching Tsang,Jialing Shen,Carol Lai-Hung Cheng,Long-Hin Tsang,Daniel W.H. Ho,David Kung-Chun Chiu,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong +12 more
TL;DR: Methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors and suggest an important mechanism of epigenetic alteration in liver carcinogenesis.
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TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
Wei Qi,Ho Man Chan,Lin Teng,Ling Li,Shannon Chuai,Ruipeng Zhang,Jue Zeng,Min Li,Hong Fan,Ying Lin,Justin Gu,Ophelia Ardayfio,Ji-Hu Zhang,Xiaoxia Yan,Jialuo Fang,Yuan Mi,Man Zhang,Tao Zhou,Grace Feng,Zijun Chen,Guobin Li,Teddy T.C. Yang,Kehao Zhao,Xianghui Liu,Zhengtian Yu,Chris Lu,Peter Atadja,En Li +27 more
TL;DR: A potent and selective small molecule inhibitor, EI1, is developed, which inhibits the enzymatic activity of Ezh2 through direct binding to the enzyme and competing with the methyl group donor S-Adenosyl methionine, providing strong validation of EzH2 as a potential therapeutic target for the treatment of cancer.
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