Journal Article10.1016/J.BBR.2013.03.019
Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis.
Johanna L. Will,Moritz Thede Eckart,Felix Rosenow,Sebastian Bauer,Wolfgang H. Oertel,Rainer K.W. Schwarting,Braxton A. Norwood +6 more
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TL;DR: Results demonstrate that a hippocampal lesion can improve performance in a rat SRTT, which supports the hypothesis that loss or impairment of hippocampal function can enhance specific task performance, especially when it is dependent on procedural (striatum-dependent) mechanisms with minimal spatial requirements.
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About: This article is published in Behavioural Brain Research. The article was published on 15 Jun 2013. The article focuses on the topics: Hippocampal sclerosis & Hippocampal formation.
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Citations
Neuroproteomics in Epilepsy: What Do We Know so Far?
Amanda Morato do Canto,Amanda Donatti,Jaqueline C Geraldis,Alexandre B Godoi,Douglas Cescon da Rosa,Iscia Lopes-Cendes +5 more
TL;DR: In this paper, the authors review the results of recent proteomic studies applied to investigate the underlying mechanisms leading to epilepsies and how these findings may impact research and treatment for these disorders.
Behavioral facilitation after hippocampal lesion: A review.
Rainer K.W. Schwarting,S. Busse +1 more
TL;DR: Hippocampal damage cannot only lead to deficits but also to behavioral facilitation, and its effects can be found in several learning paradigms, especially active avoidance, and some forms of Pavlovian and instrumental conditioning, as well as with various lesion techniques.
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RNA sequencing reveals region-specific molecular mechanisms associated with epileptogenesis in a model of classical hippocampal sclerosis.
André Schwambach Vieira,A H B de Matos,A. M. do Canto,Cristiane S. Rocha,Benilton S. Carvalho,Vinicius D'Ávila Bitencourt Pascoal,Braxton A. Norwood,Stefan Bauer,Felix Rosenow,Rovilson Gilioli,Fernando Cendes,Iscia Lopes-Cendes +11 more
TL;DR: The data presented here suggests a remarkable interaction among several molecular components which takes place in the damaged hippocampi, and even though similar mechanisms may function in different regions of the DG, the molecular components involved seem to be region specific.
Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis
Martin Meyer,Martin Meyer,Friederike Kienzler-Norwood,Friederike Kienzler-Norwood,Sebastian Bauer,Sebastian Bauer,Felix Rosenow,Felix Rosenow,Braxton A. Norwood,Braxton A. Norwood +9 more
TL;DR: LFOs are a reliable biomarker of hippocampal epileptogenesis, and removing entorhinal cortex input to the hippocampus neither reduces the occurrence of LFOs nor has a demonstrable antiepileptogenic effect.
Tiermodelle der mesialen Temporallappenepilepsie
Sebastian Bauer
- 01 Feb 2020
TL;DR: Animal models are still indispensable in experimental epilepsy research in order to overcome restrictions in clinical research and knowledge of validity criteria and limitations of these and other models are the basis for the classification of animal experimental findings.
3
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