Journal Article10.1152/JAPPL.1999.86.4.1264
Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure.
196
TL;DR: Data suggest that an enhancement of the peripheral chemoreflex occurs in the rabbit model of pacing-induced CHF and that the enhanced peripheralChemoreflex function contributes to the sympathetic activation in the CHF state.
read more
Abstract: The present study aimed to determine whether peripheral and/or central chemoreflex function is altered in chronic heart failure (CHF) and whether altered chemoreflex function contributes to sympath...
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Obstructive Sleep Apnea and Cardiovascular Disease
James M. Parish,Virend K. Somers +1 more
- 01 Aug 2004
TL;DR: Substantial evidence shows that patients with OSA have an increased incidence of hypertension compared with individuals without OSA and that OSA is a risk factor for the development of hypertension.
635
Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body
Prem Kumar,Nanduri R. Prabhakar +1 more
TL;DR: The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in knowledge.
538
Chemoreflexes--physiology and clinical implications.
TL;DR: The peripheral and central chemoreflexes have powerful effects on sympathetic activity in both health and disease and may contribute importantly to disease pathophysiology, particularly in conditions such as hypertension, obstructive sleep apnoea and heart failure.
348
Peripheral Chemoreceptor Hypersensitivity An Ominous Sign in Patients With Chronic Heart Failure
Piotr Ponikowski,T. P. Chua,Stefan D. Anker,Darrel P. Francis,Wolfram Doehner,Waldemar Banasiak,P. A. Poole-Wilson,Massimo F Piepoli,Andrew J.S. Coats +8 more
TL;DR: Hypersensitivity of the peripheral chemoreceptors independently predicts adverse prognosis in ambulatory patients with CHF, and may be the reason for the previously observed prognostic association of the latter.
323
References
Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure.
TL;DR: Whether sympathetic nerve activity is increased in patients with heart failure and whether plasma norepinephrine levels correlate with levels of mSNA in heart failure are determined and microneurography is used to directly record sympathetic nerve action to muscle.
866
A barometric method for measuring ventilation in newborn infants.
TL;DR: Minute volume, frequency, and tidal volume of premature infants measured by the barometric method are within the range of such measurements made by plethysmographic methods.
741
Control of breathing in experimental anemia.
Donald Bartlett,S.M. Tenney +1 more
TL;DR: Pulmonary ventilation was measured by a plethysmographic technique in unanesthetized, unrestrained rats and cats before and several days after they were made anemic or underwent a sham procedure, and the results were negative.
513
Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide.
TL;DR: Data indicate that an enhanced input from CB occurs in the rabbit model of pacing-induced CHF and that an impairment of NO production may contribute to this alteration.
150
Time course of sympathovagal imbalance and left ventricular dysfunction in conscious dogs with heart failure
Hisanari Ishise,Hidetsugu Asanoi,Shinji Ishizaka,Shuji Joho,Tomoki Kameyama,Katsumi Umeno,Hiroshi Inoue +6 more
TL;DR: A parallel decline in left ventricular contractility with parasympathetic influence and a parallel progression inleft ventricular diastolic dysfunction with sympathoexcitation suggest a close relationship between cardiac dysfunction and autonomic dysregulation during development of heart failure.
145