Journal Article10.1038/273759A0
Enhanced NK cell activity in mice injected with interferon and interferon inducers
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TL;DR: It is suggested that interferon may be the mediator by which many different agents increase NK cell activity in vivo, as a positive correlation exists between in vivo resistance to syngeneic tumours and the levels of NK cellActivity in the individual mice.
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Abstract: NATURAL KILLER (NK) cells constitute a distinct subgroup of cells within the immune system1,2. They are found in the lymphoid organs of several species including man and are cytolytic on contact in short-term in vitro assays for several cell types, in particular tumour cells1–5. Although the level of NK cell activity is under genetic control6,7, several extraneous agents, including bacterial adjuvants, animal viruses and NK-sensitive tumour cells induce an increase in in vivo NK cell activity6–10. Several of these agents are also known to increase the resistance of mice to transplantable tumours. This effect may be mediated by NK cells, as a positive correlation exists between in vivo resistance to syngeneic tumours and the levels of NK cell activity in the individual mice11,12. Viruses as well as several immunoadjuvants are also inducers of interferon. Here we present evidence that interferon and interferon inducers markedly enhance NK cell activity in mice, and suggest that interferon may be the mediator by which many different agents increase NK cell activity in vivo.
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Citations
Role of Natural Killer Cells and of Interferon in Natural Resistance against Virus Infections
TL;DR: There are a number of experimental findings that are fairly well established: injection of interferon causes antiviral protection in vivo, both at the infection site (for example in the peritoneal cavity) and in the serum.
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The role of interferon in the regulation of virus infections by cytotoxic lymphocytes.
TL;DR: Cytopathic viruses, which inhibit cellular RNA and protein synthesis, render target cells refractory to IFN‐mediated protection against NK cells, thereby providing a mechanism for NK cells to mediate antiviral effect by preferentially lysing virus‐infected but not uninfected cells.
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The effect of alpha-difluoromethylornithine on natural killer cell and tumoricidal macrophage induction by interferon in vivo.
TL;DR: Results indicate that DFMO is not immunosuppressive regarding antitumor cytolytic cell induction in vivo and reduces both splenic leukocyte and peritoneal macrophage polyamine levels.
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Modulation of natural killing by tumor promoters: the regulatory influence of adherent cells varies with the type of target cell.
TL;DR: It is demonstrated that the regulatory effect of tumor promoters on human NK activity (suppression or stimulation) is determined not only by macrophages at the effector cell level but also by the type of target cell under study.
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Studies of the thymus in mice bearing the Lewis lung carcinoma: I. Thymic natural killer cell activity in 3LL tumor-bearing mice☆
TL;DR: The data suggest that NK cells or their precursors are present in the thymus and can be triggered or unmasked in situ by tumor cells migrating from the primary tumor.
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References
"Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype.
TL;DR: Analysis of the kinetics of the cytotoxic assay revealed a rapid induction of lysis within one to four hours, arguing against any conventional in vitro induction of immune response.
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Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity
TL;DR: Lymphoid cells from many normal mice of a variety of inbred strains were found to have reactivity, in a 51Cr release cytotoxicity assay, against several syngeneic and allogeneic tumors, apparently associated with expression of murine endogenous type‐C viruses.
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"Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell.
TL;DR: It is concluded that the spontaneous selective cytotoxic activity of normal mouse spleen cells against Moloney leukemia cells is exerted by small lymphocytes of yet undefined nature.
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Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells
TL;DR: It is proposed that the natural cytotoxicity against mouse tumor cells is mediated by a unique subpopulation of lymphoid cells, which are tentatively designated N‐cells.
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