Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.

TL;DR: In this article, an unbiased antibody profiling approach was used to show that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, such that Ltb infection is associated with unique Ab Fc functional profiles, selective binding to FcγRIII, and distinct Ab glycosylation patterns.

TL;DR: It is shown that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, which point to a potential role for Fc-mediated Ab effector functions, tuned via differential glycosylation, in Mtb control.

TL;DR: It is proposed that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design.

TL;DR: In this paper, SARS-CoV-2 antigen-specific Fcγ receptor binding accurately distinguishes COVID-19 patients from healthy individuals, suggesting that SARS co-virus infection induces qualitative changes to antibody Fc, enhancing Fcαγ receptor engagement.

TL;DR: The model of human Fc fragment was refined at 2.9-A resolution and the R value of the model is 0.24, with strong arguments that contact 1 is the fragment B-Fc contact formed in solution under physiological conditions, while contact 2 is a crystal contact.

TL;DR: The components of the secreted and cell surface mucosal barriers and the evidence that they form an effective barricade against potential pathogens are described and dynamic alterations in the mucin barrier are described driven by host innate and adaptive immune responses to infection.

TL;DR: New molecular models of all the immunoglobulins are included to provide a basis for informed and critical discussion and to optimize the properties of therapeutic antibodies.

TL;DR: The results indicate that IgG isolated from normal individuals, patients with RA and patients with OA contains different distributions of asparagine-linked bi-antennary complex-type oligosaccharide structures, and these two arthritides may therefore be glycosylation diseases, reflecting changes in the intracellular processing, or post-secretory degradation of N-linked oligOSaccharides.