Journal Article10.1002/ADHM.201200197
Engineering the regenerative microenvironment with biomaterials.
Jeffrey J. Rice,Mikaël M. Martino,Laura De Laporte,Federico Tortelli,Priscilla S. Briquez,Jeffrey A. Hubbell +5 more
378
TL;DR: Important aspects of the healing microenvironment, and how these features can be incorporated within innovative hydrogel scaffolds, are presented.
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Abstract: Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-temporal control of the natural healing microenvironment. With increasing understanding of the role of growth factors and cytokines and their interactions with components of the extracellular matrix, novel biomaterials are being developed that more closely mimic the natural healing environments of tissues, resulting in increased efficacy in applications of tissue repair and regeneration. Herein, the important aspects of the healing microenvironment, and how these features can be incorporated within innovative hydrogel scaffolds, are presented.
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TL;DR: This review encapsulates where recent advances appear to leave the ever-shifting state of the art in the cell microenvironment, and it highlights areas in which substantial potential and uncertainty remain.
693
3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends
Elliot S. Bishop,Sami Mostafa,Mikhail Pakvasa,Hue H. Luu,Michael J. Lee,Jennifer Moriatis Wolf,Guillermo A. Ameer,Tong-Chuan He,Russell R. Reid +8 more
TL;DR: An overview of 3D bioprinting technology is provided and it is discussed that the technology holds great potential to play a key role in personalized medicine.
581
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
TL;DR: Fibrin and its heparin-binding domain is incorporated into a synthetic fibrin-mimetic matrix to prove this role in a gain-of-function model and demonstrate the benefits of generating a hybrid biomaterial consisting of a synthetic polymeric scaffold and recombinant bioactive ECM domains.
462
Electrospinning of polymer nanofibers for tissue regeneration
TL;DR: Current strategies to develop advanced nan ofibrous polymer-based scaffolds via electrospinning, their applications in regenerating human musculoskeletal tissues, and the use of polymer nanofibers to deliver growth factors or small molecules for regenerative medicine are summarized.
456
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