Patent
Engineering of strong, pliable tissues
Joseph P. Vacanti,Christopher K. Breuer,Berverly E. Chaignaud,Toshiraru Shin'oka +3 more
- 03 Nov 1998
199
TL;DR: In this paper, it has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implanting, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired.
read more
Abstract: It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired. The matrix is optionally seeded prior to the first implantation, after ingrowth of the fibrous tissue, or at the time of reimplantation. The time required for fibrous ingrowth typically ranges from days to weeks. The method is particularly useful in making valves and tubular structures, especially heart valves and blood vessels.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Hybrid biologic-synthetic bioabsorbable scaffolds
Laura J. Brown,Iksoo Chun,Sridevi Dhanaraj,Prasanna Malaviya,Mora C. Melican,Alireza Rezania,Li Zhang +6 more
- 15 Jul 2002
TL;DR: In this article, a bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction, which comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion.
814
Patent
Unitary surgical device and method
Herbert E. Schwartz,Prasanna Malaviya,Amit Kumar Singla,Pamela Lynn Plouhar,Mark Joseph Pelo +4 more
- 15 Jul 2002
TL;DR: In this article, the authors described a set of unitary surgical devices that can be used to approximate the inner surfaces of a meniscus tear and replace a void left after a menisectomy.
638
Patent
Porous extracellular matrix scaffold and method
Prasanna Malaviya,Herbert Eugene Schwartz,Pamela Lynn Plouhar,Mark Joseph Pelo +3 more
- 15 Jul 2002
TL;DR: In this article, a method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid.
433
Patent
Stent mounted valve
Henri Justino
- 22 Dec 2003
TL;DR: In this paper, a prosthetic valve is described to be inserted into a body lumen, the valve having leaflets that are spread apart during forward flow of fluid to create an orifice, and the leaflets coming into contact with each other during reverse flow of fluids, thereby impeding the reverse flow.
387
Patent
Guided development and support of hydrogel-cell compositions
Charles A. Vacanti,Joseph P. Vacanti,Martin P. Vacanti +2 more
- 22 Apr 1999
TL;DR: In this paper, the authors proposed a method for generating new tissue by obtaining a liquid hydrogel-cell composition including hydrogels and tissue precursor cells, and delivering the liquid hygelscell composition into a permeable, biocompatible support structure.
317
References
Patent
Implantable material and appliances and method of stabilizing body implants
Charles A. Homsy
- 17 Oct 1974
TL;DR: In this article, the authors proposed a composition of material suitable for in vivo implantation to provide an environment in which normal tissue growth is fostered which composition is a porous fibrous structure in which the critical surface tension of the fibers is 35 dynes per centimeter or higher.
153
Patent
Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
Dana C. Mears
- 26 Feb 1981
TL;DR: In this paper, a method of repair of patient tissues by implant including providing a living cell sample which is introduced into an implant member having a porous open structure is described, where the cell sample may be cultured in the implant.
153
Patent
Treated tissue for implantation and methods of treatment and use
E. Christopher Orton
- 05 Mar 1991
TL;DR: The preferred growth factor is basic fibroblast growth factor, and the preferred cells are fibroblasts as discussed by the authors, which can be an allograft or xenograft taken from a cow, pig or other mammal.
151
Patent
Device and method for treating and healing a newly created bone void
John H. Brekke
- 21 Nov 1977
TL;DR: In this paper, a one piece moldable body having a form sufficient to cover a bone void and made of a biodegradable material is presented for treating a newly created bone void or soft tissue deficiency.
149
Ectopic induction of cartilage and bone by water-soluble proteins from bovine bone using a polyanhydride delivery vehicle.
Paul A. Lucas,Cato T. Laurencin,Glenn T. Syftestad,Abraham J. Domb,Victor M. Goldberg,Arnold I. Caplan,Robert Langer +6 more
TL;DR: It is demonstrated that it is possible to use polyanhydride polymers as controlled-release delivery vehicles for soluble bioactive factors that interact with a local cell population.
149
Related Papers (5)
Gail K. Naughton,Brian A. Naughton +1 more
- 06 Apr 1995
Joseph P. Vacanti,Anthony Atala,David J. Mooney,Robert Langer +3 more
- 15 Dec 1995