Endothelin and its inhibitors
Bruno Battistini,Timothy D. Warner +1 more
- 01 Jan 2001
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TL;DR: Endothelin Ligands and Their Experimental Effects Within the Human Circulation and the Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis are explained.
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Abstract: 1. Historical Perspective and Introduction.- 2. Sarafotoxins.- 3. Endothelin-Converting Enzymes.- 4. Endothelin Receptors.- 5. Cell Signalling by Endothelin Peptides.- 6. Gene Deletion of Endothelin Systems.- 7. Endothelin-Converting Enzyme Inhibitors.- 8. Endothelin-Converting Enzymes and Endothelin Receptor Localisation in Human Tissues.- 9. Endothelin Receptor Antagonists.- 10. Toxicology of Endothelin Antagonists.- 11. Release of Autacoids.- 12. The Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis.- 13. Endothelins in Cerebral Vasospasms and Strokes.- 14. Airway Reactivity and Disease.- 15. Endothelin-1 and Pulmonary Hypertension.- 16. Vascular and Cardiac Effects.- 17. Liver and Gastrointestinal System.- 18. Endothelins and the Kidney.- 19. Endothelin Ligands and Their Experimental Effects Within the Human Circulation.The complete table of contents can be found on the Internet: http://www.springer.de
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Citations
Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing.
TL;DR: A variety of approaches ranging from molecular and genetic investigations to human clinical studies were recommended to further investigate the important epidemiologic associations and a large number of tests were identified to assess specific mechanistic pathways underlying the cardiovascular effects of air pollution.
164
Function of the endothelinB receptor in cardiovascular physiology and pathophysiology
Pedro D'Orléans-Juste,Julie Labonté,Ghassan Bkaily,Sanaa Choufani,Mirco Plante,Jean-Claude Honoré +5 more
TL;DR: The most recent literature supports the use of selective ET( AR) antagonists rather than mixed antagonists of ET(AR)s and ET(BR)s for the management of congestive heart failure, renal failure and primary pulmonary hypertension, but validation of this view will have to await the first clinical trials comparing the actions ofET(A) to mixed ET(A)/ET(B) receptor antagonists.
152
Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium
TL;DR: The presence of ETA and ETB receptors in human myocardium and the atrioventricular conducting system is demonstrated and mRNA for both subtypes was detected in isolated atrial myocytes.
81
Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
TL;DR: Analysis of the gene expression profile of ET-1-stimulated mesangial cells demonstrates that an autocrine signaling loop involving MCP-1 and IL-6 contributes to ET- 1-induced collagen accumulation.
68
Immunoreactive circulating endothelin‐1 in normal and hypertensive pregnancies
TL;DR: It is concluded that increased endothelin-1 production may play a role in the pathogenesis of preeclampsia and six to 10 weeks after delivery the mean levels of 15 studied patients were similar to the levels of the nonpregnant control women.
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Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: investigations using the selective inhibitors, 1400W and celecoxib
TL;DR: In conclusion, the use of selective inhibitors does not support the concept of cross talk in vivo between iNOS and COX‐2.
65
Nonpeptide endothelin antagonist. Cerebrovascular characterization and effects on delayed cerebral vasospasm.
TL;DR: The results suggest that ET plays a significant role in the development of delayed cerebral vasospasm via an interaction with ETA receptors, and ETA receptor antagonists may represent a novel therapeutic approach to the treatment of subarachnoid hemorrhage.
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Neonatal Lethality in Mice Deficient in XCE, a Novel Member of the Endothelin-converting Enzyme and Neutral Endopeptidase Family
Anja Schweizer,Olivier Valdenaire,Anja Köster,Yolande Lang,Georg Schmitt,Barbara Lenz,Horst Bluethmann,Jack Rohrer +7 more
TL;DR: The phenotype of the XCE-deficient mice together with the central nervous system-specific expression further suggest that XCE may play a vital role in the control of respiration.
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Hepatic effects of endothelin. Receptor characterization and endothelin-induced signal transduction in hepatocytes.
TL;DR: The presence of multiple high-affinity receptors for ET-1 on hepatocytes and the direct action of this peptide on hepatic parenchymal cells via the phosphoinositide signal transduction pathway is demonstrated.
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Increased Endothelin-Like Immunoreactive Material on Bronchoalveolar Lavage Fluid from Patients with Bronchial Asthma and Patients with Interstitial Lung Disease
Matteo Sofia,Mauro Mormile,Stanislao Faraone,Marco Alifano,Sergio Zofra,Luigi Romano,L. Carratù +6 more
TL;DR: Though rarely detected on BALf from normal lungs, ET increases on BALF in patients with bronchopulmonary disease, raising the question of its involvement in pathogenic mechanisms or evolution of bronchial asthma and interstitial lung disease.
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