Endothelin and its inhibitors
Bruno Battistini,Timothy D. Warner +1 more
- 01 Jan 2001
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TL;DR: Endothelin Ligands and Their Experimental Effects Within the Human Circulation and the Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis are explained.
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Abstract: 1. Historical Perspective and Introduction.- 2. Sarafotoxins.- 3. Endothelin-Converting Enzymes.- 4. Endothelin Receptors.- 5. Cell Signalling by Endothelin Peptides.- 6. Gene Deletion of Endothelin Systems.- 7. Endothelin-Converting Enzyme Inhibitors.- 8. Endothelin-Converting Enzymes and Endothelin Receptor Localisation in Human Tissues.- 9. Endothelin Receptor Antagonists.- 10. Toxicology of Endothelin Antagonists.- 11. Release of Autacoids.- 12. The Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis.- 13. Endothelins in Cerebral Vasospasms and Strokes.- 14. Airway Reactivity and Disease.- 15. Endothelin-1 and Pulmonary Hypertension.- 16. Vascular and Cardiac Effects.- 17. Liver and Gastrointestinal System.- 18. Endothelins and the Kidney.- 19. Endothelin Ligands and Their Experimental Effects Within the Human Circulation.The complete table of contents can be found on the Internet: http://www.springer.de
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TL;DR: The concentration of immunoreactive endothelin in the inner medulla of the kidney was remarkably decreased in spontaneously hypertensive rats (SHR) compared with normotensive control Wistar Kyoto rats (WKY) but no difference was observed in lung immunore Active Endothelin.
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Inhibition by salbutamol of the proliferation of human airway smooth muscle cells grown in culture.
TL;DR: The results indicate that salbutamol, through activation of a β2‐adrenoceptor, has a direct inhibitory effect on proliferation elicited by the mitogens thrombin, EGF, and U46619, and it seems likely that thisdirect inhibitory action of β2-adrenOceptor agonists would override any indirect action to accelerate airway smooth muscle proliferation.
120
Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock.
Denis R. Morel,Jean-Silvain Lacroix,Anette Hemsén,D.A. Steinig,Jean-Francois Pittet,Jan M. Lundberg +5 more
TL;DR: Arterial and mixed venous blood and pulmonary lymph samples were collected, together with continuous measurement of pulmonary and systemic haemodynamics in six awake sheep receiving a constant rate intravenous infusion of Escherichia coli endotoxin dissolved in sterile normal saline.
119
Oxyhemoglobin stimulation of endothelin production in cultured endothelial cells.
TL;DR: The present results reveal that oxyhemoglobin can directly stimulate endothelin biosynthesis in cultured endothelial cells, suggesting a potential mechanism for the sustained and severe cerebral vasospasm associated with subarachnoid hemorrhage.
119
Endothelin A Receptor Blockade Causes Adverse Left Ventricular Remodeling but Improves Pulmonary Artery Pressure After Infarction in the Rat
Quang Trinh Nguyen,Peter Cernacek,Angelino Calderoni,Duncan J. Stewart,Pierre Picard,Pierre Sirois,Michel White,Jean L. Rouleau +7 more
TL;DR: The early use of the ETA receptor antagonists LU 127043 or its active enantiomer LU 135252 after infarction in the rat leads to impaired scar healing and LV dilatation and dysfunction, accompanied by a decrease in RV systolic and right atrial pressures and a decreases in pulmonary but not cardiac ET-1 levels.
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