Endothelin and its inhibitors
Bruno Battistini,Timothy D. Warner +1 more
- 01 Jan 2001
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TL;DR: Endothelin Ligands and Their Experimental Effects Within the Human Circulation and the Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis are explained.
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Abstract: 1. Historical Perspective and Introduction.- 2. Sarafotoxins.- 3. Endothelin-Converting Enzymes.- 4. Endothelin Receptors.- 5. Cell Signalling by Endothelin Peptides.- 6. Gene Deletion of Endothelin Systems.- 7. Endothelin-Converting Enzyme Inhibitors.- 8. Endothelin-Converting Enzymes and Endothelin Receptor Localisation in Human Tissues.- 9. Endothelin Receptor Antagonists.- 10. Toxicology of Endothelin Antagonists.- 11. Release of Autacoids.- 12. The Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis.- 13. Endothelins in Cerebral Vasospasms and Strokes.- 14. Airway Reactivity and Disease.- 15. Endothelin-1 and Pulmonary Hypertension.- 16. Vascular and Cardiac Effects.- 17. Liver and Gastrointestinal System.- 18. Endothelins and the Kidney.- 19. Endothelin Ligands and Their Experimental Effects Within the Human Circulation.The complete table of contents can be found on the Internet: http://www.springer.de
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Function of the endothelinB receptor in cardiovascular physiology and pathophysiology
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Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium
TL;DR: The presence of ETA and ETB receptors in human myocardium and the atrioventricular conducting system is demonstrated and mRNA for both subtypes was detected in isolated atrial myocytes.
81
Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
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Immunoreactive circulating endothelin‐1 in normal and hypertensive pregnancies
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References
Endothelin synthesis by rabbit renal tubule cells.
TL;DR: De novo synthesis of ET-3 by cultured IMCD cells is confirmed, raising the possibility of an important functional role for nephron-derived endothelin and, in particular,endothelin produced by tubule cells in the medulla.
158
Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1
TL;DR: Intravenous injection of big endothelin-1 to anaesthetized rats produced a dose-dependent and long-lasting hypertensive effect, the magnitude of which was similar to that evoked by ET-1, and in animals given phosphoramidon (0.25 mg/kg per min i.v.), a metalloproteinase inhibitor, the hypertensive result was markedly attenuated.
158
N-phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors
De Lombaert S,Erion,Jenny Tan,L. Blanchard,L. El‐Chehabi,R. D. Ghai,Yumi Sakane,Carol Berry,Angelo J. Trapani +8 more
TL;DR: The alpha-aminomethyl phosphonate 18 represents a new generation of selective NEP inhibitors that combine high potency, long duration of action, and oral bioavailability and holds promise as a novel therapeutic agent for the treatment of human hypertension and congestive heart failure.
157
Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation.
TL;DR: Experiments were designed to examine the role of endothelin (ET) receptors, specifically ETA receptors, in mediating the renal vasoconstrictor effects of ET-1 in anesthetized Sprague-Dawley rats.
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