Endothelin and its inhibitors
Bruno Battistini,Timothy D. Warner +1 more
- 01 Jan 2001
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TL;DR: Endothelin Ligands and Their Experimental Effects Within the Human Circulation and the Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis are explained.
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Abstract: 1. Historical Perspective and Introduction.- 2. Sarafotoxins.- 3. Endothelin-Converting Enzymes.- 4. Endothelin Receptors.- 5. Cell Signalling by Endothelin Peptides.- 6. Gene Deletion of Endothelin Systems.- 7. Endothelin-Converting Enzyme Inhibitors.- 8. Endothelin-Converting Enzymes and Endothelin Receptor Localisation in Human Tissues.- 9. Endothelin Receptor Antagonists.- 10. Toxicology of Endothelin Antagonists.- 11. Release of Autacoids.- 12. The Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis.- 13. Endothelins in Cerebral Vasospasms and Strokes.- 14. Airway Reactivity and Disease.- 15. Endothelin-1 and Pulmonary Hypertension.- 16. Vascular and Cardiac Effects.- 17. Liver and Gastrointestinal System.- 18. Endothelins and the Kidney.- 19. Endothelin Ligands and Their Experimental Effects Within the Human Circulation.The complete table of contents can be found on the Internet: http://www.springer.de
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Citations
Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing.
TL;DR: A variety of approaches ranging from molecular and genetic investigations to human clinical studies were recommended to further investigate the important epidemiologic associations and a large number of tests were identified to assess specific mechanistic pathways underlying the cardiovascular effects of air pollution.
164
Function of the endothelinB receptor in cardiovascular physiology and pathophysiology
Pedro D'Orléans-Juste,Julie Labonté,Ghassan Bkaily,Sanaa Choufani,Mirco Plante,Jean-Claude Honoré +5 more
TL;DR: The most recent literature supports the use of selective ET( AR) antagonists rather than mixed antagonists of ET(AR)s and ET(BR)s for the management of congestive heart failure, renal failure and primary pulmonary hypertension, but validation of this view will have to await the first clinical trials comparing the actions ofET(A) to mixed ET(A)/ET(B) receptor antagonists.
152
Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium
TL;DR: The presence of ETA and ETB receptors in human myocardium and the atrioventricular conducting system is demonstrated and mRNA for both subtypes was detected in isolated atrial myocytes.
81
Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
TL;DR: Analysis of the gene expression profile of ET-1-stimulated mesangial cells demonstrates that an autocrine signaling loop involving MCP-1 and IL-6 contributes to ET- 1-induced collagen accumulation.
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Immunoreactive circulating endothelin‐1 in normal and hypertensive pregnancies
TL;DR: It is concluded that increased endothelin-1 production may play a role in the pathogenesis of preeclampsia and six to 10 weeks after delivery the mean levels of 15 studied patients were similar to the levels of the nonpregnant control women.
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References
Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.
TL;DR: The present data suggest that in guinea‐pig isolated trachea, ET‐1 produces contraction predominantly via a direct mechanism: there is no significant contribution of the release of histamine, leukotrienes, PAF, or tachykinins (acting on NK1 or NK2 receptors).
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Relative Contribution of Endothelin A and Endothelin B Receptors to Vasoconstriction in Small Arteries from Human Heart and Brain
TL;DR: Data suggest that ETA receptors predominate on the smooth-muscle layer of human small pial arteries, and that Coronary arteries also express mainly ETA receptor receptors, although a small population of contractile ETB receptors may also be present in some patients.
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Endothelin-1 potently stimulates chloride secretion and inhibits Na(+)-glucose absorption in human intestine in vitro.
Michaela Kuhn,M. Fuchs,F X Beck,S. Martin,J Jähne,Jürgen Klempnauer,V Kaever,Gerhard Rechkemmer,W G Forssmann +8 more
TL;DR: The results suggest different cellular action sites for ET‐1 in human small and large intestine are suggested, namely the rapid inhibition of electrogenic Na(+)‐glucose absorption, which might be mediated by an inhibition of the transport activity of SGLT1.
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Comparison of a novel ETA receptor antagonist and phosphoramidon in renal ischemia.
TL;DR: The results suggest that both ETA and non-ETA receptors mediate ET-induced changes in ischemic renal failure.
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Local formation and degradation of endothelin-1 in guinea pig airway tissues.
Kazuhito Noguchi,Takahiro Fukuroda,Yukiko Ikeno,Hiroyasu Hirose,Yasuko Tsukada,Masaru Nishikibe,Fumihiko Ikemoto,Kenji Matsuyama,Mitsuo Yano +8 more
TL;DR: The results suggest that ET converting as well as degrading enzymes coexist in the airway tissue and both enzymes are sensitive to phosphoramidon, so that phosphor amidon acts bifunctionally to reduce and stimulate the airways responses to big ET-1.
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