Book Chapter10.1007/978-3-030-03589-1_12
Endophytic Fungi: Promising Source of Novel Bioactive Compounds
Fazilath Uzma,Chakrabhavi Dhananjaya Mohan,Chandra Nayaka Siddaiah,Srinivas Chowdappa +3 more
- 01 Jan 2019
- pp 243-265
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TL;DR: The main focus of this chapter is to provide a concise approach to the origin, classification, host-endophyte symbiosis, and the endophytic fungal role in diverse areas such as plant growth enhancers, antimicrobials, anticancer agents, and antioxidants.
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Abstract: Natural products have been used since earliest times for the treatment of several ailments. They offer excellent prospects for discovery of bioactive compounds and are the basis for the synthesis of effective drugs. Natural products from endophytic fungi of medicinal plants have been recognized as potential sources of bioactive compounds. Endophytes exemplify a diverse microbial community that exists in distinct environments and their diversity in these unique habitats benefits in the exploration of novel bioactive compounds. Fungal endophytes occur ubiquitously in plants and are generally asymptomatic within the host plants. The mutualistic association of a plant with an endophyte could influence the production of analogous bioactive compounds as the host plant. An understanding of biologically active compound production mechanism and their activity is essential for the development of new compounds in the drug discovery process. From the time when taxol, a potent anticancer compound was discovered, research on endophytic fungi has gained momentum and yielded several compounds with antibacterial, antiviral, antioxidant, immunosuppressant, anti-inflammatory, anti-diabetic, and anticancer properties. The main focus of this chapter is to provide a concise approach to the origin, classification, host-endophyte symbiosis, and the endophytic fungal role in diverse areas such as plant growth enhancers, antimicrobials, anticancer agents, and antioxidants. This chapter aims to highlight the potential benefits of secondary metabolites of endophytic fungi in varied fields which are valuable to mankind.
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Citations
Untapped Potentials of Endophytic Fungi: A Review of Novel Bioactive Compounds with Biological Applications.
Madira Coutlyne Manganyi,Collins Njie Ateba +1 more
- 06 Dec 2020
TL;DR: Special emphasis is placed on the antimicrobial and antiviral activities of metabolites produced by endophytes against human pathogens, and the importance of utilization of these compounds as potential treatment agents for serious life-threatening infectious diseases is highlighted.
179
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature
Chakrabhavi Dhananjaya Mohan,Shobith Rangappa,Habbanakuppe D. Preetham,S. Chandra Nayaka,Vijai Kumar Gupta,Salundi Basappa,Gautam Sethi,Kanchugarakoppal S. Rangappa +7 more
TL;DR: This review has provided a comprehensive overview of mechanisms of STAT3 signal transduction and its endogenous negative modulators, the role ofSTAT3 in oncogenesis, the interplay of miRNAs in STAT3 signaling, and mechanisms involved in persistent activation of stat3.
124
Fungal Endophyte-Mediated Crop Improvement: The Way Ahead.
Vijaya R Chitnis,Trichur S. Suryanarayanan,Karaba N. Nataraja,S Rajendra Prasad,Ralf Oelmüller,R. Uma Shaanker,R. Uma Shaanker +6 more
TL;DR: The need to study various facets of the endophyte-plant association for their gainful application in agriculture is stressed and some of the important bottlenecks that might stand in way of fully realizing the potential that endophytes hold for crop improvement are elaborate.
Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
Ragi Jadimurthy,Shilpa Borehalli Mayegowda,Sushma Nayak,Chakrabhavi Dhananjaya Mohan,Kanchugarakoppal S. Rangappa +4 more
TL;DR: In this article , the authors have discussed the mechanisms acquired by ESKAPE organisms to counteract the effect of antibiotics and elaborated on recently discovered secondary metabolites derived from bacteria and plant sources that are endowed with good antibacterial activity towards pathogenic bacteria in general, ESkAPE organisms in particular.
46
Bioprocessing strategies for cost-effective large-scale biogenic synthesis of nano-MgO from endophytic Streptomyces coelicolor strain E72 as an anti-multidrug-resistant pathogens agent.
TL;DR: This is the first report using statistical nanobiotechnological strategies to study and evaluate the endophytic S. coelicolor biomass production and extract the highest bioactive metabolites used for biogenic synthesis of nano-MgO through exponential sucrose pulses feeding fermentation strategy.
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