Journal Article10.1007/BF02715905
Endogamy, consanguinity and community genetics.
207
TL;DR: In populations where consanguineous marriage is widely practised, recessive genetic disorders will continue to gain greater prominence in the overall spectrum of ill health, but at the same time this increase will in part be negated by urbanization and the move to smaller family sizes, which predictably will result in a decline in the prevalence of consanguinity.
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Abstract: The population of India is composed of many thousands of subpopulations, divided by geography, language, religion and caste or biraderi (patrilineage) boundaries, with endogamous marriage the norm. The net effect has been the creation of multiple genetic isolates with individual mutation profiles, but to date the clinical consequences of this highly complex differentiation have been largely ignored. In contrast, the topic of consanguinity continues to attract attention among medical and population geneticists, clinicians and social scientists. The significant progress made in India in improving childhood nutritional status and combating infectious disease means that genetic disorders have assumed everincreasing importance. In populations where consanguineous marriage is widely practised, recessive genetic disorders will continue to gain greater prominence in the overall spectrum of ill health. At the same time this increase will in part be negated by urbanization and the move to smaller family sizes, which predictably will result in a decline in the prevalence of consanguineous unions. Developing an understanding of these changes will require a wide-ranging and multidisciplinary investigative approach for which community genetics is ideally suited.
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References
Trends in consanguineous marriage in Karnataka, South India, 1980–89
TL;DR: Analysis of data on 106,848 marriages in the cities of Bangalore and Mysore, South India, between 1980 and 1989 showed that levels of consanguineous marriage varied between cities through time and by religion.
•Book Chapter
Inbreeding in human populations: An assessment of the costs
Alan H. Bittles,E. Makov +1 more
- 01 Jan 1988
TL;DR: The aim of the present chapter is to provide an overall assessment of the risks associated with various degrees of human inbreeding at the population, as opposed to the individual or group, level.
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•Journal Article
Incidence of inbreeding in different states of India.
TL;DR: This paper summarizes a study on the comparison of inbreeding incidence in several states of India and discusses the four kinds of first cousin marriages which is considered the most frequent type of consanguineous marriage for all religious communities and tribes in India.
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Clinical findings, consanguinity, and pedigrees in children with anophthalmos in southern India.
TL;DR: Clinical findings, pedigrees, and possible environmental risk factors in children with clinical anophthalmos and remnant microphthalmos in either eye in southern India are described and high rates of consanguinity suggest a genetic recessive aetiology.
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