Journal Article10.1016/S0021-9673(00)00951-1
Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers.
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TL;DR: The possible contribution of enantioselective chromatography with respect to the preparation ofEnantiomerically pure compounds is reviewed in the context of the competitive approaches and depending on the application scale, with a special emphasis on the recent progresses achieved in this particular field of separation.
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About: This article is published in Journal of Chromatography A. The article was published on 12 Jan 2001. The article focuses on the topics: Enantioselective synthesis.
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Citations
Analytical and semipreparative high performance liquid chromatography enantioseparation of new substituted 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazoles on polysaccharide-based chiral stationary phases in normal-phase, polar organic and reversed-phase conditions.
Roberto Cirilli,A Simonelli,Rosella Ferretti,Adriana Bolasco,Paola Chimenti,Daniela Secci,Elias Maccioni,F. La Torre +7 more
TL;DR: Chiralpak IA exhibited an excellent chiral resolving ability in normal-phase mode and it allowed the enantioseparation of analytes investigated with resolution factors >20, and was successfully employed at analytical and semipreparative scale in combination with normal- phase eluents containing "non-standards" solvents such as acetone.
54
Mechanistic investigations of cinchona alkaloid-based zwitterionic chiral stationary phases.
TL;DR: By application of slightly acidic polar organic mobile phases as preferred elution mode, it is found that certain amounts of aprotic acetonitrile in protic methanol substantially increased enantioselectivity and resolution of amino acids in a structure-dependent manner.
54
Chiral stationary phases and applications in gas chromatography.
Gloria Betzenbichler,Laura Huber,Sabrina Kräh,Marie-Louise K Morkos,Alexander F. Siegle,O. E. Trapp +5 more
TL;DR: In this paper , a review of the development of chiral stationary phases for gas chromatography is presented, focusing on the fundamental mechanisms of the recognition and separation of enantiomers and the selectors and CHs used in CHs.
54
A resolution approach of racemic phenylalanine with aqueous two-phase systems of chiral tropine ionic liquids.
TL;DR: The results indicate that d-enantiomer of phenylalanine interacts more strongly with chiral ILs and Cu(2+) based on the chiral ion-pairs space coordination mechanism, which makes it tend to remain in the top IL-rich phase, by contrast, l- enantiomer is transferred into the solid phase.
54
Generic chiral method development in supercritical fluid chromatography and ultra-performance supercritical fluid chromatography
TL;DR: A generic chiral separation strategy for SFC proved its applicability and efficiency with the successful separation of a novel 20-compound test set and even more benefit may be expected in ultra-performance SFC when customized sub-2 μm chiral stationary phases will become available.
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Quinine and quinidine derivatives as chiral selectors I. Brush type chiral stationary phases for high-performance liquid chromatography based on cinchonan carbamates and their application as chiral anion exchangers
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Ganapathy Subramanian
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TL;DR: In this article, an introduction to enantioseparation by liquid chromatography regulatory implications and chiral separations modelling enantiodifferentiation in chiral chromatography enantiomer separation using tailormade phases prepared by molecular imprinting cyclodextrin bonded chiral stationary phases.