Emotion recognition and experience in Huntington's disease: Is there a differential impairment?
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TL;DR: HD patients gave lower intensity ratings for facial expressions of anger, disgust and surprise than controls and their classification accuracy was reduced for angry, disgusted, sad and surprised faces, which points to a differential impairment in emotion recognition and emotion experience in HD.
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Abstract: Findings on affective processing deficits in Huntington's disease (HD) have been inconsistent. It is still not clear whether HD patients are afflicted by specific deficits in emotion recognition and experience. We tested 28 symptomatic HD patients and presented them with pictures depicting facial expressions of emotions (Karolinska-Set) and with affective scenes (International Affective Picture System; IAPS). The faces were judged according to the displayed intensity of six basic emotions, whereas the scenes received intensity ratings for the elicited emotions in the viewer. Patients' responses were compared with those of 28 healthy controls. HD patients gave lower intensity ratings for facial expressions of anger, disgust and surprise than controls. Patients' recognition deficits were associated with reduced functional capacity, such as problems with social interactions. Moreover, their classification accuracy was reduced for angry, disgusted, sad and surprised faces. When judging affective scenes for the elicitation of happiness, disgust and fear, HD patients had a tendency to estimate them as more intense than controls. This finding points to a differential impairment in emotion recognition and emotion experience in HD. We found no significant correlations between emotion experience/recognition ratings and CAG repeats, symptom duration and UHDRS Motor Assessment in the patient group.
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Citations
Structural MRI in Huntington's disease and recommendations for its potential use in clinical trials.
Nellie Georgiou-Karistianis,Rachael I. Scahill,Sarah J. Tabrizi,Ferdinando Squitieri,Elizabeth Aylward +4 more
TL;DR: A review of the current structural imaging literature in HD and recommendations for the standardisation of reporting for future studies are made, including appropriate cohort characterisation and documentation of methodologies to facilitate comparisons and inform trial design.
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Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease.
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TL;DR: The disrupted motor grounding hypothesis is introduced, a new framework to conceive such impairments as disturbances of embodied mechanisms (high‐order domains based on the recycling of functionally germane sensorimotor circuits) in Parkinson's and Huntington's disease.
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