Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug
TL;DR: In this article , a phytosynthesis method was used to prepare ZnO nanoparticles (ZnO NPs) via Senna alata L. leaf extract (SALE) by involving alkaloids, which played an essential role as a source of weak bases during the formation reaction of NPs.
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Abstract: Abstract The phytosynthesis method was used to prepare ZnO nanoparticles (ZnO NPs) via Senna alata L. leaf extract (SALE) by involving alkaloids, which play an essential role as a source of weak bases during the formation reaction of NPs. ZnO NPs on glassy carbon electrodes (GCE/ZnO NP) have been introduced to investigate its electrochemical activity towards the antiretroviral drug, lamivudine (3TC). Several characterization techniques, such as Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDS), and Dynamic Light Scattering (DLS) techniques were employed to analyze the properties of GCE/ZnO NPs. As a result, ZnO NPs in spherical shape showed a high purity crystalline hexagonal wurtzite structure with a particle diameter of 40–60 nm. A Cyclic Voltammetry (CV) measurement confirmed that the electrochemical reduction of 3TC on GCE/ZnO NPs exhibited an excellent linear range of 10–300 µM with a detection limit of 1.902 µM, quantitation limit of 6.330 µM, and sensitivity of 0.0278 µA/µM. Thus, this research suggests a facile method for the preparation of material-based ZnO NPs as a promising antiretroviral drug sensors due to their excellent electrochemical properties.
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Citations
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TL;DR: Single-fluid electrospinning of shellac fibers loaded with Senna alata leaf extract creates nanofibers with high entrapment efficiency and sustained release of the extract. The process optimization yielded fibers with a diameter of 306 nm, a low bead-to-fiber ratio of 0.29, and an extract entrapment efficiency of 96%.
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Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract
Wah Wah Aung,Wantanwa Krongrawa,Sontaya Limmatvapirat,Pattranit Kulpicheswanich,Siriporn Okonogi,Chutima Limmatvapirat +5 more
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TL;DR: Single-fluid electrospinning of shellac fibers loaded with Senna alata leaf extract creates nanofibers with high entrapment efficiency and sustained release of the extract. The process optimization yielded fibers with diameter of 306 nm, low bead-to-fiber ratio of 0.29, and entrapment efficiency of 96%. The biphasic release profile and antimicrobial efficacy of the optimized nanofibers suggest potential applications in wound dressings and protective textiles.
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