Journal Article10.1111/J.1460-9568.2011.07878.X
Electrical activity patterns and the functional maturation of the neocortex
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TL;DR: Current knowledge on the origin of early electrical activity patterns in neocortical sensory areas and their functional implications on shaping developing cortical networks are reviewed.
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Abstract: At the earliest developmental stages, sensory neocortical areas in various species reveal distinct patterns of spontaneous neuronal network activity. These activity patterns either propagate over large neocortical areas or synchronize local neuronal ensembles. In vitro and in vivo experiments indicate that these spontaneous activity patterns are generated from neuronal networks in the cerebral cortex, in subcortical structures or in the sensory periphery (retina, cochlea, whiskers). At early stages spontaneous periphery-driven and also sensory evoked activity is relayed to the developing cerebral cortex via the thalamus and the neocortical subplate, which amplifies the afferent sensory input. These early local and large-scale neuronal activity patterns influence a variety of developmental processes during corticogenesis, such as neurogenesis, apoptosis, neuronal migration, differentiation and network formation. The experimental data also indicate that disturbances in early neuronal patterns may have an impact on the development of cortical layers, columns and networks. In this article we review our current knowledge on the origin of early electrical activity patterns in neocortical sensory areas and their functional implications on shaping developing cortical networks.
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Citations
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TL;DR: A wealth of recent findings are discussed that have advanced the understanding of the developmental mechanisms that contribute to the diversification of interneurons and suggest areas of particular promise for further investigation.
290
Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions.
Heiko J. Luhmann,Anne Sinning,Jenq-Wei Yang,Vicente Reyes-Puerta,Maik C. Stüttgen,Sergei Kirischuk,Werner Kilb +6 more
TL;DR: Early spontaneous activity patterns control the formation of developing networks in sensory cortices, and disturbances of these activity patterns may lead to long-lasting neuronal deficits.
Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B-/- mice
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Neural histology and neurogenesis of the human fetal and infant brain.
TL;DR: The microstructural organization and neural circuitry elements of the fetal and early postnatal human cerebrum are described and the genetic, genomic, and molecular biology data on phenotypic specification of developing brain regions, areas and neurons are included.
188
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